APIXAGRESS 5 10'S

About

Apixaban is a direct oral anticoagulant (DOAC) that functions as a selective, reversible inhibitor of Factor Xa, a crucial enzyme in the coagulation cascade. By blocking both free and clot-bound Factor Xa, apixaban effectively prevents the generation of thrombin and subsequent thrombus formation. This mechanism makes it highly effective in the prevention and treatment of various thromboembolic disorders, including stroke prevention in atrial fibrillation and treatment of deep vein thrombosis and pulmonary embolism. Unlike traditional anticoagulants such as warfarin, apixaban offers predictable pharmacokinetics and pharmacodynamics, eliminating the need for routine coagulation monitoring, which simplifies patient management. Its clinical profile demonstrates a favorable balance between efficacy in preventing thrombotic events and a reduced risk of major bleeding complications, particularly intracranial hemorrhage, making it a valuable option for patients requiring long-term anticoagulation therapy with improved safety and convenience.

Uses

• Prevention of stroke and systemic embolism in non-valvular atrial fibrillation (NVAF).
• Treatment of deep vein thrombosis (DVT).
• Treatment of pulmonary embolism (PE).
• Prophylaxis of DVT following hip or knee replacement surgery.

Directions For Use

Take orally as directed by your physician, usually twice daily, with or without food.

Benefits

• Effective in preventing blood clots.
• Lower risk of intracranial hemorrhage compared to warfarin.
• No routine coagulation monitoring required.
• Convenient oral administration.
• Rapid onset of action.
• Fewer drug-food interactions than warfarin.

Side Effects

• Bleeding (e.g., nosebleeds, gum bleeding)
• Bruising easily
• Gastrointestinal bleeding
• Hematuria (blood in urine)
• Rectal bleeding
• Anemia
• Nausea
• Fatigue
• Dizziness
• Rash
• Hypersensitivity reactions
• Increased risk of major bleeding events

Safety Measures

• Alcohol - Moderate alcohol consumption may be acceptable, but excessive intake can increase bleeding risk. Consult your doctor.
• Pregnancy - Generally not recommended during pregnancy due to potential fetal bleeding risk. Discuss alternatives with your doctor.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant. Seek medical advice.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustment may be necessary.
• Kidney - Dose adjustment may be required in patients with moderate to severe renal impairment. Regular monitoring is advised.
• Lung - No specific contraindications related to lung conditions, but use with caution in patients with active pulmonary hemorrhage.

Disclaimer

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