APIXAPIL 2.5 10S

About

Apixaban is a direct oral anticoagulant that selectively inhibits Factor Xa, a crucial enzyme in the coagulation cascade responsible for initiating and propagating blood clot formation. By blocking Factor Xa, apixaban effectively reduces thrombin generation and subsequent fibrin clot development. The 2.5mg dosage is specifically indicated for certain patient populations and clinical scenarios, such as the prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing elective hip or knee replacement surgery. It is also used for stroke prevention in a subset of patients with non-valvular atrial fibrillation who meet specific criteria, including advanced age, low body weight, or impaired renal function, where a lower dose is deemed appropriate. This precise dosing allows for tailored anticoagulation, offering a predictable and effective antithrombotic effect without the need for routine coagulation monitoring, thereby enhancing patient convenience and safety in specific high-risk settings.

Uses

• Prophylaxis of DVT in patients undergoing hip or knee replacement surgery.
• Prevention of stroke and systemic embolism in specific non-valvular atrial fibrillation patients.
• Prevention of recurrent DVT and PE after initial treatment.
• Management of certain thrombotic conditions under specialist guidance.

Directions For Use

Take exactly as prescribed by your doctor, usually twice daily. Do not stop taking this medication without consulting your physician.

Benefits

• Effective in preventing blood clots, especially post-surgery.
• Does not require routine blood monitoring.
• Lower risk of major bleeding compared to warfarin.
• Convenient oral administration.
• Rapid onset of action.
• Predictable pharmacokinetic profile.

Side Effects

• Bleeding (e.g., nosebleeds, gum bleeding)
• Bruising
• Nausea
• Anemia
• Rash
• Gastrointestinal bleeding
• Hematuria (blood in urine)
• Rectal bleeding
• Headache
• Dizziness
• Fatigue
• Allergic reactions (rare)

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of bleeding, especially gastrointestinal bleeding.
• Pregnancy - Not recommended during pregnancy due to potential for fetal bleeding. Use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and pose a risk to the infant.
• Liver - Use with caution in patients with severe liver impairment as it may increase bleeding risk. Not recommended in severe hepatic disease.
• Kidney - Dosage adjustment may be necessary in patients with moderate to severe kidney impairment. Regular monitoring is advised.
• Lung - No specific contraindications related to lung conditions, but use cautiously in patients with active pulmonary hemorrhage.

Disclaimer

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