APIXAPIL 5 10S

About

Apixaban is a highly effective oral anticoagulant that functions as a direct, selective inhibitor of Factor Xa, a pivotal enzyme within the intrinsic and extrinsic coagulation pathways. By specifically blocking Factor Xa, apixaban significantly curtails the generation of thrombin, thereby impeding the formation of fibrin clots. This mechanism allows for a predictable anticoagulant effect without the necessity for routine coagulation monitoring, which is a considerable advantage over traditional anticoagulants like warfarin. Its primary clinical applications include the prevention of stroke and systemic embolism in patients diagnosed with non-valvular atrial fibrillation, as well as the treatment and secondary prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE). Apixaban's favorable pharmacokinetic profile, characterized by rapid absorption and a relatively short half-life, coupled with a generally lower incidence of major bleeding events compared to vitamin K antagonists, positions it as a valuable therapeutic option in the long-term management of various thrombotic disorders.

Uses

• Prevention of stroke and systemic embolism in non-valvular atrial fibrillation.
• Treatment of deep vein thrombosis (DVT).
• Treatment of pulmonary embolism (PE).
• Prevention of recurrent DVT and PE.

Directions For Use

Take exactly as prescribed by your doctor, usually twice daily. Do not stop taking this medication without consulting your physician.

Benefits

• Effective in preventing blood clots.
• Does not require routine blood monitoring.
• Lower risk of major bleeding compared to warfarin.
• Convenient oral administration.
• Rapid onset of action.
• Predictable pharmacokinetic profile.

Side Effects

• Bleeding (e.g., nosebleeds, gum bleeding)
• Bruising
• Nausea
• Anemia
• Rash
• Gastrointestinal bleeding
• Hematuria (blood in urine)
• Rectal bleeding
• Headache
• Dizziness
• Fatigue
• Allergic reactions (rare)

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of bleeding, especially gastrointestinal bleeding.
• Pregnancy - Not recommended during pregnancy due to potential for fetal bleeding. Use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and pose a risk to the infant.
• Liver - Use with caution in patients with severe liver impairment as it may increase bleeding risk. Not recommended in severe hepatic disease.
• Kidney - Dosage adjustment may be necessary in patients with moderate to severe kidney impairment. Regular monitoring is advised.
• Lung - No specific contraindications related to lung conditions, but use cautiously in patients with active pulmonary hemorrhage.

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