BEMPESTA TAB 10S

About

Bempedoic acid, often found under brand names like BEMPESTA, is an oral medication used to lower low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia or established atherosclerotic cardiovascular disease (ASCVD) who require additional LDL-C lowering. It works by inhibiting adenosine triphosphate-citrate lyase (ACL), an enzyme involved in cholesterol synthesis in the liver, upstream of HMG-CoA reductase (the target of statins). This mechanism reduces cholesterol production and increases the uptake of LDL-C from the blood.

Bempedoic acid is particularly useful for patients who cannot tolerate statins due to muscle-related side effects or those who need further LDL-C reduction despite maximal statin therapy. It is often prescribed in combination with statins or other lipid-lowering therapies. Clinical trials have demonstrated its efficacy in significantly reducing LDL-C levels and improving cardiovascular outcomes. Regular monitoring of lipid profiles and liver function is recommended during treatment to ensure safety and effectiveness.

Uses

• Lowers LDL-C in primary hypercholesterolemia.
• Reduces cardiovascular risk in ASCVD patients.
• Used in patients intolerant to statins.
• Adjunct to diet and other lipid-lowering therapies.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Significantly lowers LDL-C levels.
• Offers an alternative for statin-intolerant patients.
• Reduces risk of major cardiovascular events.
• Can be combined with other lipid-lowering drugs.
• Well-tolerated by many patients.
• Improves overall lipid profile.

Side Effects

• Hyperuricemia (increased uric acid).
• Gout.
• Muscle spasms.
• Back pain.
• Abdominal pain.
• Anemia.
• Elevated liver enzymes.
• Bronchitis.
• Pain in extremities.
• Diarrhea.
• Nausea.
• Fatigue.

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol can affect liver; consult a doctor.
• Pregnancy - Not recommended; potential for fetal harm. Consult a doctor immediately if pregnant.
• Breastfeeding - Not recommended; unknown if excreted in human milk. Consult a doctor.
• Liver - Use with caution in severe hepatic impairment; monitor liver enzymes regularly.
• Kidney - Use with caution in severe renal impairment; dose adjustment may be needed.
• Lung - Generally safe; no specific contraindications for lung conditions.

Disclaimer

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