Biceltis 440mg Injection

About

Trastuzumab is a monoclonal antibody that specifically targets the human epidermal growth factor receptor 2 (HER2) protein, which is overexpressed in certain aggressive types of breast cancer and gastric cancer. By binding to HER2, trastuzumab inhibits the growth and proliferation of cancer cells that rely on this receptor for signaling. Its mechanism involves both direct inhibition of HER2 signaling pathways and activation of antibody-dependent cell-mediated cytotoxicity (ADCC), leading to the destruction of HER2-positive cancer cells. This targeted approach minimizes damage to healthy cells. Administered intravenously, trastuzumab is a cornerstone in the treatment of HER2-positive early-stage and metastatic breast cancer, as well as HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. It is often used in combination with chemotherapy or as a single agent. Cardiac function monitoring is crucial during treatment due to the risk of cardiotoxicity, a significant adverse effect.

Uses

• HER2-positive metastatic breast cancer
• HER2-positive early-stage breast cancer
• HER2-positive metastatic gastric cancer
• HER2-positive gastroesophageal junction adenocarcinoma

Directions For Use

Administered intravenously by a healthcare professional. Dosage is based on body weight, and treatment duration varies by indication.

Benefits

• Specifically targets HER2-positive cancers.
• Significantly improves survival in HER2-positive breast cancer.
• Can be used in both early and metastatic settings.
• Often combined with chemotherapy for enhanced efficacy.
• Reduces the risk of recurrence in early breast cancer.
• Available in an injectable form for systemic delivery.

Side Effects

• Cardiotoxicity (heart failure, decreased ejection fraction)
• Infusion-related reactions (fever, chills, nausea)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Abdominal pain
• Myalgia (muscle pain)
• Arthralgia (joint pain)
• Neutropenia (low white blood cell count)
• Pulmonary toxicity (rare)

Safety Measures

• Alcohol - No specific interaction with alcohol, but general moderation is advised.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm; use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk.
• Liver - Use with caution in patients with liver impairment; monitor liver function tests.
• Kidney - Generally safe in kidney impairment, but monitor for potential accumulation of metabolites.
• Lung - Use with caution in patients with pre-existing lung conditions; monitor for pulmonary toxicity.

Disclaimer

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