Calcium Folinate 15mg Injection

About

Calcium Folinate 15mg Injection, also known as Leucovorin, is a form of folic acid that does not require reduction by dihydrofolate reductase to be active. It is primarily used in oncology as a 'rescue' agent to counteract the toxic effects of folic acid antagonists, particularly methotrexate, which is a potent chemotherapy drug. By providing a readily available source of reduced folates, Calcium Folinate protects healthy cells from methotrexate's cytotoxic effects, especially in the bone marrow and gastrointestinal tract, thereby preventing severe myelosuppression and mucositis. Additionally, it is used to enhance the cytotoxic effects of fluorouracil in the treatment of various cancers and can be used to treat megaloblastic anemia due to folate deficiency.

Uses

• Methotrexate rescue therapy
• Potentiation of fluorouracil in cancer treatment
• Treatment of megaloblastic anemia due to folate deficiency
• Antidote for pyrimethamine overdose

Directions For Use

Administer intravenously or intramuscularly as directed by a physician, according to specific treatment protocols.

Benefits

• Reduces severe methotrexate toxicity
• Enhances the efficacy of fluorouracil
• Prevents myelosuppression and mucositis
• Supports healthy cell division and DNA synthesis
• Essential for certain metabolic processes
• Versatile in various oncological settings

Side Effects

• Allergic reactions (rare)
• Fever
• Nausea
• Vomiting
• Diarrhea
• Rash
• Itching
• Stomatitis
• Insomnia
• Agitation
• Seizures (rare, with high doses)
• Flushing
• Headache
• Dizziness

Safety Measures

• Alcohol - No direct interaction, but alcohol can worsen folate deficiency. Consult your doctor regarding alcohol consumption.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. Consult a physician before use.
• Breastfeeding - Use with caution; it is unknown if calcium folinate is excreted in breast milk. Consult a physician.
• Liver - Generally safe for use in patients with liver conditions; no specific dose adjustment is typically needed.
• Kidney - Use with caution in severe kidney impairment; monitor folate levels and renal function closely.
• Lung - No specific concerns or contraindications related to lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.