Carbobuzz 450mg Injection

About

Carbobuzz 450mg Injection is a platinum-based chemotherapy agent, commonly known as Carboplatin, used in the treatment of various cancers. It works by forming highly reactive platinum complexes that bind to DNA, leading to intra-strand and inter-strand crosslinks. These crosslinks interfere with DNA replication and transcription, ultimately inhibiting cell division and inducing apoptosis in rapidly dividing cancer cells. Carbobuzz is often preferred over cisplatin due to its generally milder side effect profile, particularly regarding nephrotoxicity and ototoxicity, while maintaining significant anti-tumor activity. It is administered intravenously and is a cornerstone in the treatment of ovarian, lung, head and neck, and testicular cancers, often used in combination with other chemotherapeutic agents.

Uses

• Treatment of advanced ovarian carcinoma.
• Management of small cell lung cancer.
• Treatment of non-small cell lung cancer.
• Used in germ cell tumors and head and neck cancers.

Directions For Use

Administered intravenously by a healthcare professional. Dosage is calculated based on body surface area or renal function.

Benefits

• Broad-spectrum anti-cancer activity.
• Effective in various solid tumors.
• Often used in combination regimens.
• Generally better tolerated than cisplatin.
• Induces DNA damage in cancer cells.
• Contributes to tumor regression.

Side Effects

• Myelosuppression (thrombocytopenia, neutropenia, anemia)
• Nausea
• Vomiting
• Peripheral neuropathy
• Ototoxicity (hearing loss)
• Alopecia (hair loss)
• Fatigue
• Electrolyte disturbances
• Hypersensitivity reactions
• Nephrotoxicity (kidney damage)
• Mucositis
• Diarrhea

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may increase gastrointestinal upset and potentially exacerbate liver strain.
• Pregnancy - Contraindicated in pregnancy due to severe teratogenic effects. Women of childbearing potential must use highly effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if the drug is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment. Liver function should be monitored regularly.
• Kidney - Dose adjustment is crucial in patients with renal impairment. Renal function must be closely monitored before and during treatment.
• Lung - Monitor for rare interstitial lung disease. Patients with pre-existing lung conditions should be carefully assessed.

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