CHLORAMAX 2 MG TAB. 1X30 TAB.

About

Chlorambucil is an orally administered alkylating agent, a foundational chemotherapy drug utilized in the treatment of chronic lymphocytic leukemia (CLL), certain types of non-Hodgkin's lymphoma, and Waldenström's macroglobulinemia. Its therapeutic action stems from its ability to form highly reactive carbonium ions that covalently bind to and cross-link DNA strands. This irreversible DNA damage disrupts critical cellular processes such as DNA replication and transcription, leading to cell cycle arrest and programmed cell death, particularly in rapidly proliferating malignant cells. The convenience of its oral formulation makes it a valuable option for long-term disease management, offering a well-tolerated profile while effectively reducing tumor burden and controlling disease progression.

Uses

• Chronic lymphocytic leukemia (CLL)
• Hodgkin's lymphoma
• Non-Hodgkin's lymphoma
• Waldenström's macroglobulinemia

Directions For Use

Take orally as directed by your physician. Dosage and schedule are individualized based on the specific condition and patient response.

Benefits

• Effective oral chemotherapy option.
• Well-established efficacy in CLL.
• Generally well-tolerated compared to other alkylating agents.
• Can be used as monotherapy or in combination.
• Convenient for outpatient administration.
• Contributes to disease control and symptom management.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Diarrhea
• Oral ulceration
• Skin rash
• Fever
• Hepatotoxicity (rare)
• Pulmonary fibrosis (rare, long-term)
• Seizures (rare, high doses)
• Secondary malignancies (rare, long-term)
• Infertility
• Allergic reactions

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may increase gastrointestinal irritation and potentially exacerbate liver toxicity.
• Pregnancy - Chlorambucil is teratogenic and embryotoxic. It is contraindicated in pregnancy; effective contraception is mandatory for both male and female patients.
• Breastfeeding - Breastfeeding is contraindicated during chlorambucil therapy due to the potential for serious adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests regularly. Dose adjustments may be necessary.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function tests regularly. Dose adjustments may be necessary.
• Lung - Rare but serious pulmonary toxicity, including interstitial pneumonitis and pulmonary fibrosis, can occur. Monitor for respiratory symptoms.

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