Clokeran 5mg Tablet

About

Clokeran 5mg Tablet contains Chlorambucil, an alkylating agent used in chemotherapy for various types of cancer. This medication works by interfering with the DNA replication and transcription processes within cancer cells. It forms cross-links in DNA strands, preventing cell division and leading to cell death. This cytotoxic action is particularly effective against rapidly dividing cells, such as those found in malignant tumors.

Chlorambucil is a well-established oral chemotherapy agent, often preferred for its relatively mild side effect profile compared to some other cytotoxic drugs, especially in chronic conditions. It is primarily used in the treatment of certain leukemias, lymphomas, and ovarian carcinoma. Due to its potent effects on cell proliferation, careful monitoring of blood counts and other parameters is essential throughout the treatment course to manage potential adverse reactions and ensure therapeutic efficacy.

Uses

• Treatment of chronic lymphocytic leukemia (CLL)
• Management of Hodgkin's lymphoma
• Treatment of certain non-Hodgkin's lymphomas
• Therapy for ovarian carcinoma

Directions For Use

Take orally, usually once daily, as prescribed by an oncologist. Do not crush or chew the tablet.

Benefits

• Effective in treating specific types of cancer
• Can induce remission in eligible patients
• Slows the progression of certain malignancies
• Oral administration offers convenience
• Well-established treatment protocol
• Manageable side effect profile for long-term use

Side Effects

• Bone marrow suppression (anemia, neutropenia, thrombocytopenia)
• Nausea
• Vomiting
• Diarrhea
• Oral ulcers (stomatitis)
• Skin rash
• Hair thinning (alopecia)
• Liver toxicity
• Lung fibrosis (rare)
• Seizures (rare)
• Infertility
• Secondary malignancies (long-term risk)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase liver toxicity and gastrointestinal upset.
• Pregnancy - Absolutely contraindicated. Highly teratogenic; effective contraception must be used by both male and female patients.
• Breastfeeding - Absolutely contraindicated. The drug passes into breast milk; discontinue breastfeeding during treatment.
• Liver - Use with extreme caution. Dose adjustment may be necessary, and liver function must be closely monitored.
• Kidney - Use with caution. Dose adjustment may be necessary, and kidney function must be closely monitored.
• Lung - Caution is advised in patients with pre-existing lung disease; monitor for signs of pulmonary fibrosis.

Disclaimer

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