CYCLOPHIL ME 25 5S

About

CYCLOPHIL ME 25 contains Cyclosporine, a potent immunosuppressant belonging to the calcineurin inhibitor class. It works by selectively inhibiting the activation of T-lymphocytes, which are crucial cells in the immune response responsible for attacking foreign tissues and cells. This action helps to prevent the body's immune system from rejecting transplanted organs such as kidneys, liver, or heart, by suppressing the immune response against the new organ.

Beyond organ transplantation, Cyclosporine is also utilized in the management of severe autoimmune conditions where the immune system mistakenly attacks the body's own tissues. Its microemulsion formulation (ME) enhances its absorption and bioavailability, leading to more consistent drug levels in the blood, which is vital for effective immunosuppression and minimizing adverse effects. Regular monitoring of blood levels is essential to optimize therapy and ensure patient safety.

Uses

• Prevention of organ transplant rejection (kidney, liver, heart)
• Treatment of severe active rheumatoid arthritis
• Management of severe psoriasis
• Treatment of severe, steroid-dependent nephrotic syndrome

Directions For Use

Take exactly as prescribed by your doctor, usually twice daily. Maintain a consistent schedule and method of administration.

Benefits

• Effectively prevents organ transplant rejection
• Manages severe autoimmune diseases
• Improves quality of life for transplant recipients
• Reduces inflammation in chronic conditions
• Allows for steroid-sparing in some patients
• Helps preserve transplanted organ function

Side Effects

• Kidney dysfunction (nephrotoxicity)
• High blood pressure (hypertension)
• Increased hair growth (hirsutism)
• Gum overgrowth (gingival hyperplasia)
• Tremor
• Headache
• Gastrointestinal upset (nausea, vomiting, diarrhea)
• Increased risk of infections
• Increased risk of certain cancers (lymphoma, skin cancer)
• High cholesterol and triglycerides (hyperlipidemia)
• High potassium levels (hyperkalemia)
• Liver dysfunction (hepatotoxicity)

Safety Measures

• Alcohol - Alcohol consumption should be avoided or strictly limited due to potential for increased liver toxicity and interaction with the medication's metabolism.
• Pregnancy - Cyclosporine is generally not recommended during pregnancy unless the potential benefits outweigh the risks. It can cross the placenta and may be associated with fetal harm. Discuss risks with your doctor.
• Breastfeeding - Cyclosporine passes into breast milk and can cause serious adverse effects in a nursing infant. Breastfeeding is generally not recommended while taking this medication.
• Liver - Use with extreme caution in patients with liver impairment. Dose adjustments may be necessary, and liver function should be monitored closely due to the risk of hepatotoxicity.
• Kidney - Cyclosporine is known to cause dose-dependent nephrotoxicity. Regular monitoring of kidney function (creatinine, BUN) is crucial, and dose adjustments are often required, especially in patients with pre-existing kidney conditions.
• Lung - While not directly toxic to the lungs, immunosuppression can increase the risk of opportunistic lung infections. Patients should report any respiratory symptoms promptly.

Disclaimer

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