DAPAVEL 10 10S

About

DAPAVEL 10 contains Dapagliflozin, an oral antidiabetic medication belonging to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine. This mechanism helps to lower blood glucose levels independently of insulin, making it effective in managing type 2 diabetes mellitus. Beyond glycemic control, Dapagliflozin has demonstrated significant cardiovascular and renal benefits, reducing the risk of cardiovascular death, hospitalization for heart failure, and progression of chronic kidney disease in eligible patients.

Its action also contributes to modest weight loss and blood pressure reduction, offering a multifaceted approach to diabetes management. It is used as monotherapy or in combination with other antidiabetic agents when diet and exercise alone are insufficient to achieve adequate glycemic control.

Uses

• Management of type 2 diabetes mellitus
• Reduction of cardiovascular risk in type 2 diabetes patients with established cardiovascular disease
• Reduction of hospitalization for heart failure
• Management of chronic kidney disease

Directions For Use

Take orally once daily, with or without food, as directed by your physician.

Benefits

• Effectively lowers blood glucose levels
• Promotes modest weight loss
• Reduces blood pressure
• Provides cardiovascular protection
• Offers renal protective effects
• Reduces risk of hospitalization for heart failure

Side Effects

• Urinary tract infections (UTIs)
• Genital yeast infections
• Increased urination
• Thirst
• Dizziness
• Low blood pressure (hypotension)
• Ketoacidosis (rare)
• Kidney problems
• Back pain
• Nausea
• Constipation
• Fournier's gangrene (very rare)

Safety Measures

• Alcohol - Alcohol consumption may increase the risk of dehydration and, if combined with other medications like metformin, the risk of lactic acidosis. Use with caution.
• Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters, due to potential adverse effects on fetal kidney development. Consult your doctor.
• Breastfeeding - It is not recommended during breastfeeding as it may pass into breast milk and affect the infant. Consult your doctor.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustment may be necessary.
• Kidney - Contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73m²). Regular monitoring of kidney function is essential.
• Lung - Generally no direct lung effects. However, monitor for fluid status, as severe dehydration could indirectly impact respiratory function.

Disclaimer

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