Defcort 12 mg

About

Defcort 12 mg contains deflazacort, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It acts as a prodrug, rapidly converting to its active metabolite, 21-desacetyl deflazacort, which then binds to glucocorticoid receptors. This interaction modulates gene expression, leading to a reduction in the synthesis of inflammatory mediators and suppression of immune cell function. Deflazacort is often chosen for its potentially lower impact on bone metabolism and glucose tolerance compared to other corticosteroids, although individual responses vary.

It is widely used in the management of a broad spectrum of inflammatory, allergic, and autoimmune conditions, including Duchenne muscular dystrophy, rheumatoid arthritis, and severe allergic reactions. The therapeutic effects are dose-dependent, and long-term use necessitates careful monitoring for adverse effects such as adrenal suppression, osteoporosis, and metabolic disturbances. Gradual tapering of the dose is crucial upon discontinuation to prevent withdrawal symptoms and adrenal crisis.

Uses

• Treatment of Duchenne muscular dystrophy.
• Management of severe allergic reactions.
• Treatment of inflammatory conditions like arthritis.
• Suppression of the immune system in autoimmune diseases.

Directions For Use

Take orally with food as directed by your doctor. Do not stop abruptly.

Benefits

• Potent anti-inflammatory action.
• Effective immunosuppressant.
• May have a better bone safety profile than other corticosteroids.
• Useful in a wide range of inflammatory and autoimmune disorders.
• Available in convenient oral dosage forms.
• Helps manage symptoms and improve quality of life.

Side Effects

• Weight gain
• Increased appetite
• Fluid retention
• Mood changes (irritability, anxiety)
• Insomnia
• Increased blood sugar levels
• High blood pressure
• Osteoporosis (long-term use)
• Adrenal suppression
• Increased susceptibility to infections
• Muscle weakness
• Cataracts or glaucoma (long-term use)

Safety Measures

• Alcohol - Limit alcohol intake as it may increase the risk of gastrointestinal irritation and bone density loss.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Small amounts may pass into breast milk. Use with caution and under medical supervision.
• Liver - Use with caution in patients with severe liver disease; dose adjustments may be necessary.
• Kidney - Generally safe in kidney conditions, but monitor for fluid retention and electrolyte imbalances.
• Lung - Used to treat various lung conditions; monitor for infections, especially with long-term use.

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