DEFLOGRAF 30TAB 1X10

About

Deflograf 30TAB, likely referring to Deflazacort, is a glucocorticoid with potent anti-inflammatory and immunosuppressive properties. Unlike some other corticosteroids, Deflazacort is designed to potentially have a more favorable side effect profile, particularly concerning bone density and glucose metabolism, at equivalent anti-inflammatory doses. It exerts its effects by binding to specific glucocorticoid receptors within cells, which then modulates gene expression to reduce the production of inflammatory mediators and suppress immune cell activity. This action makes it effective in treating a wide range of inflammatory, allergic, and autoimmune conditions.

Its primary clinical application includes the treatment of Duchenne muscular dystrophy (DMD), where it helps to preserve muscle strength and function, and delay disease progression. Additionally, it is used in conditions such as rheumatoid arthritis, asthma, systemic lupus erythematosus, and various allergic disorders. The therapeutic goal is to reduce inflammation, alleviate symptoms, and suppress undesirable immune responses, thereby improving the quality of life for patients with chronic inflammatory or autoimmune diseases.

Uses

• Treatment of Duchenne muscular dystrophy (DMD).
• Management of rheumatoid arthritis.
• Control of severe asthma and allergic conditions.
• Treatment of inflammatory bowel disease.

Directions For Use

Take orally, typically once daily, with or after food to minimize gastrointestinal upset. Follow your doctor's prescribed dosage and schedule.

Benefits

• Potent anti-inflammatory and immunosuppressive effects.
• Helps preserve muscle strength and function in DMD.
• May have a more favorable bone and glucose profile than other corticosteroids.
• Effective in managing various autoimmune and allergic conditions.
• Reduces pain and swelling associated with inflammation.
• Improves quality of life for patients with chronic conditions.

Side Effects

• Weight gain
• Increased appetite
• Fluid retention (edema)
• Mood changes (irritability, anxiety, depression)
• Insomnia
• Hyperglycemia (elevated blood sugar)
• Osteoporosis (bone thinning)
• Increased risk of infections
• Cataracts and glaucoma
• Adrenal suppression
• Hypertension
• Gastrointestinal upset

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of gastrointestinal irritation and may exacerbate potential liver effects.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. It can cross the placenta, so consult your doctor.
• Breastfeeding - Excreted in breast milk. Caution is advised, and a doctor should be consulted to monitor the infant for potential adverse effects.
• Liver - Use with caution; dose adjustment may be needed in severe hepatic impairment due to altered drug metabolism.
• Kidney - Use with caution; dose adjustment may be needed in severe renal impairment. Monitor fluid and electrolyte balance.
• Lung - Can worsen existing lung infections (e.g., tuberculosis) and increase susceptibility to new ones. Monitor for respiratory symptoms.

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