About

Deferasirox is an oral iron chelator specifically designed to reduce chronic iron overload in patients who receive frequent blood transfusions, a common necessity for conditions such as thalassemia, sickle cell disease, and myelodysplastic syndromes. Its mechanism involves binding to excess iron in the body, forming a stable complex that is subsequently excreted, predominantly via the feces. This crucial chelating action is vital for preventing and mitigating the severe organ damage that can result from iron accumulation, particularly affecting vital organs like the liver, heart, and various endocrine glands. Consistent monitoring of serum ferritin levels, liver function, and renal parameters is an integral part of the treatment regimen to ensure optimal therapeutic efficacy and to promptly identify and manage any potential adverse reactions, thereby optimizing patient safety and treatment success.

Uses

Treatment of chronic iron overload due to blood transfusions.
Management of iron overload in non-transfusion-dependent thalassemia syndromes.
Prevention of organ damage from excessive iron accumulation.
Reduction of serum ferritin levels in iron-overloaded patients.

Directions For Use

Take orally once daily on an empty stomach, at least 30 minutes before food. Dissolve the dispersible tablets in water or orange juice.

Benefits

Effectively reduces systemic iron overload.
Helps prevent iron-induced organ damage.
Available in convenient oral formulation.
Improves quality of life for transfusion-dependent patients.
Can be used in various iron overload conditions.
Supports long-term management of chronic iron accumulation.

Side Effects

Nausea
Vomiting
Diarrhea
Abdominal pain
Skin rash
Headache
Increased serum creatinine
Elevated liver enzymes
Proteinuria
Hearing loss
Vision disturbances
Renal tubular dysfunction

Safety Measures

Alcohol - Avoid excessive alcohol consumption as it may increase the risk of liver damage, a potential side effect of this medication.
Pregnancy - Use during pregnancy only if the potential benefit justifies the potential risk to the fetus, as animal studies have shown adverse effects. Consult a doctor.
Breastfeeding - It is unknown if this medication passes into breast milk. A decision should be made whether to discontinue breastfeeding or the drug, considering the importance of the drug to the mother.
Liver - Use with caution in patients with pre-existing liver impairment. Regular monitoring of liver function tests is essential.
Kidney - Use with caution in patients with renal impairment. Regular monitoring of serum creatinine and proteinuria is required.
Lung - Generally not directly associated with lung conditions, but overall patient health should be considered.

Disclaimer

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