About
Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid naturally present in small amounts in human bile, widely used in the treatment of various hepatobiliary disorders. Its primary actions include reducing the cholesterol saturation of bile, which facilitates the dissolution of cholesterol gallstones and prevents the formation of new ones. In cholestatic liver diseases, such as primary biliary cholangitis (PBC), UDCA works by replacing more toxic endogenous bile acids, protecting hepatocytes from damage, and improving bile flow. It also exhibits immunomodulatory properties, which contribute to its efficacy in slowing the progression of certain autoimmune liver conditions. By altering the composition of bile and exerting cytoprotective effects, UDCA helps to improve liver function tests and clinical outcomes for patients with specific liver and gallbladder conditions.
Uses
- Dissolution of small to medium cholesterol gallstones.
- Treatment of primary biliary cholangitis (PBC).
- Management of cholestatic liver diseases.
- Prevention of gallstone formation in rapid weight loss.
Directions For Use
Take orally with food, usually divided into 2-3 doses daily. Follow your doctor's specific instructions.
Benefits
- Dissolves cholesterol gallstones.
- Improves liver function in cholestatic diseases.
- Slows progression of primary biliary cholangitis.
- Reduces symptoms like pruritus in liver disease.
- Protects hepatocytes from toxic bile acids.
- Generally well-tolerated.
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Constipation
- Dyspepsia
- Pruritus (itching)
- Rash
- Hair thinning
- Dizziness
- Fatigue
- Allergic reactions (rare)
Safety Measures
- Alcohol - Limit alcohol intake as it can worsen liver conditions and reduce the effectiveness of the medication.
- Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. Consult a doctor.
- Breastfeeding - Small amounts may pass into breast milk; use with caution and consult a doctor.
- Liver - Generally used to treat liver conditions; however, contraindicated in acute inflammation of the gallbladder or bile ducts.
- Kidney - No specific dosage adjustment is typically required for kidney impairment.
- Lung - Generally safe for use in patients with lung conditions; no specific precautions are usually required.
Disclaimer
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