DOMITEX -R 10

About

Domitex-R is a widely utilized combination medication, typically formulated with Domperidone and Rabeprazole, designed to address a spectrum of gastrointestinal issues. Rabeprazole, a potent proton pump inhibitor (PPI), functions by irreversibly binding to and blocking the H+/K+-ATPase enzyme system, commonly known as the proton pump, located in the gastric parietal cells. This action leads to a profound and sustained reduction in gastric acid secretion. Domperidone, on the other hand, is a dopamine antagonist that acts as a prokinetic agent, enhancing gastrointestinal motility and significantly accelerating gastric emptying, which helps in reducing reflux. Furthermore, it possesses antiemetic properties by blocking dopamine receptors in the chemoreceptor trigger zone, thereby alleviating nausea and vomiting. This synergistic combination proves highly effective in the comprehensive treatment of conditions such as gastroesophageal reflux disease (GERD), functional dyspepsia, and other acid-related disorders where both robust acid suppression and improved gastrointestinal motility are therapeutically advantageous.

Uses

• Treatment of Gastroesophageal Reflux Disease (GERD)
• Management of dyspepsia and heartburn
• Relief of nausea and vomiting
• Treatment of peptic ulcers (as adjunct)

Directions For Use

Take one capsule once daily, preferably before breakfast, or as directed by your doctor. Swallow whole, do not chew or crush.

Benefits

• Reduces stomach acid production
• Alleviates heartburn and acid reflux
• Relieves nausea and vomiting
• Improves gastric emptying
• Promotes healing of esophageal erosions
• Provides symptomatic relief from dyspepsia

Side Effects

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence
• Dry mouth
• Dizziness
• Rash
• Fatigue
• Constipation
• Increased prolactin levels (Domperidone)
• Bone fractures (long-term PPI use)

Safety Measures

• Alcohol - No specific interaction, but alcohol can irritate the stomach and worsen GERD symptoms.
• Pregnancy - Not generally recommended unless clearly necessary. Consult a doctor.
• Breastfeeding - Domperidone passes into breast milk; not recommended. Rabeprazole also passes into breast milk.
• Liver - Use with caution and dose adjustment in patients with severe liver impairment.
• Kidney - Use with caution in patients with severe kidney impairment.
• Lung - No specific contraindications, but long-term PPI use may be associated with an increased risk of community-acquired pneumonia.

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