ENZAMIDE 160MG CAPS 7'S

About

Enzamide 160mg Capsules contain Enzalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. This medication works by blocking multiple steps in the androgen receptor signaling pathway, which is crucial for the growth and survival of prostate cancer cells. By inhibiting androgen binding to the receptor, preventing nuclear translocation of the androgen receptor, and impairing DNA binding and transcription, Enzalutamide effectively reduces the proliferation of cancer cells and induces apoptosis.

It is primarily indicated for patients with metastatic castration-resistant prostate cancer (mCRPC), regardless of prior chemotherapy treatment. Enzalutamide offers a significant therapeutic advantage by extending survival and delaying disease progression in this patient population. Its oral administration provides convenience, though strict adherence to the prescribed regimen is essential for optimal outcomes. Regular monitoring for efficacy and side effects is crucial throughout the treatment course.

Uses

• Treatment of metastatic castration-resistant prostate cancer (mCRPC)
• Management of non-metastatic castration-resistant prostate cancer (nmCRPC)
• Used in patients who have previously received docetaxel chemotherapy
• Also indicated for patients who are chemotherapy-naive

Directions For Use

Take 160 mg (four 40 mg capsules) orally once daily, with or without food. Swallow capsules whole; do not chew, dissolve, or open.

Benefits

• Significantly prolongs overall survival in mCRPC patients
• Delays disease progression and time to chemotherapy initiation
• Reduces the risk of skeletal-related events
• Offers an effective oral treatment option
• Improves quality of life by controlling cancer symptoms
• Demonstrates efficacy in both pre- and post-chemotherapy settings

Side Effects

• Fatigue
• Hot flashes
• Hypertension (high blood pressure)
• Headache
• Diarrhea
• Musculoskeletal pain
• Falls
• Seizures (rare but serious)
• Peripheral edema
• Nausea
• Dizziness
• Cognitive impairment

Safety Measures

• Alcohol - Alcohol consumption should be limited or avoided as it may increase the risk of certain side effects, including seizures.
• Pregnancy - Enzalutamide is not indicated for women. It can cause fetal harm if administered to a pregnant woman.
• Breastfeeding - Enzalutamide is not indicated for women. It is unknown if it is excreted in human milk.
• Liver - Use with caution in patients with severe hepatic impairment. Dose adjustment may be necessary.
• Kidney - No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
• Lung - No specific precautions for lung conditions are typically noted, but any new or worsening respiratory symptoms should be reported to a doctor.

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