FIBROCEDE 25 10S

About

FIBROCEDE 25 contains Fenofibrate, a fibric acid derivative primarily used to manage dyslipidemia. It works by activating peroxisome proliferator-activated receptor alpha (PPARα), which leads to increased lipolysis and elimination of triglyceride-rich particles from plasma. This action results in a significant reduction in plasma triglycerides and a moderate reduction in LDL-cholesterol, while also increasing HDL-cholesterol levels. Fenofibrate is particularly effective in patients with severe hypertriglyceridemia and mixed dyslipidemia, where elevated triglycerides pose a significant cardiovascular risk. Its mechanism also involves reducing the synthesis of very low-density lipoprotein (VLDL) and increasing the catabolism of triglyceride-rich lipoproteins. The 25mg dosage is typically a lower strength, often used for maintenance or in patients requiring less aggressive lipid modification, or as part of a broader lipid management strategy.

Uses

• Treatment of severe hypertriglyceridemia.
• Management of mixed dyslipidemia.
• Reduction of elevated LDL-cholesterol in certain patients.
• Increasing HDL-cholesterol levels.

Directions For Use

Take one tablet orally once daily with a meal, or as directed by your physician. Swallow the tablet whole; do not crush or chew.

Benefits

• Effectively lowers high triglyceride levels.
• Helps reduce "bad" LDL-cholesterol.
• Increases "good" HDL-cholesterol.
• Reduces the risk of pancreatitis in severe hypertriglyceridemia.
• Improves overall lipid profile.
• Supports cardiovascular health when combined with lifestyle changes.

Side Effects

• Abdominal pain
• Nausea
• Diarrhea
• Constipation
• Headache
• Back pain
• Muscle pain (myalgia)
• Elevated liver enzymes
• Rash
• Fatigue
• Insomnia
• Dizziness

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase triglyceride levels and potentially exacerbate liver side effects associated with fenofibrate.
• Pregnancy - Generally not recommended during pregnancy unless the potential benefits outweigh the risks. Consult a doctor.
• Breastfeeding - It is unknown if fenofibrate is excreted in human milk. Use with caution and under medical supervision.
• Liver - Contraindicated in patients with active liver disease or unexplained persistent liver function abnormalities. Regular monitoring of liver enzymes is required.
• Kidney - Use with caution and at reduced dosages in patients with moderate to severe renal impairment. Contraindicated in severe renal disease.
• Lung - No specific contraindications related to lung conditions, but general caution applies to patients with multiple comorbidities.

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