FRITOLEV XR 1000MG 10 TAB

About

Levetiracetam XR (Extended Release) is an antiepileptic drug (AED) primarily used in the treatment of various seizure disorders. Its precise mechanism of action is not fully understood but is believed to involve binding to the synaptic vesicle protein 2A (SV2A) in the brain, which modulates neurotransmitter release and helps to normalize neuronal excitability. The extended-release formulation allows for once-daily dosing, which can improve patient adherence and provide more consistent drug levels throughout the day, reducing fluctuations that might trigger seizures. Levetiracetam is effective as monotherapy or adjunctive therapy for partial-onset seizures, and as adjunctive therapy for myoclonic seizures in patients with juvenile myoclonic epilepsy and primary generalized tonic-clonic seizures. It is generally well-tolerated compared to some older AEDs, with a favorable pharmacokinetic profile and minimal drug-drug interactions.

Uses

• Monotherapy or adjunctive therapy for partial-onset seizures.
• Adjunctive therapy for myoclonic seizures in juvenile myoclonic epilepsy.
• Adjunctive therapy for primary generalized tonic-clonic seizures.
• Prevention of seizures in certain neurological conditions.

Directions For Use

Take this medication orally once daily, with or without food, as prescribed by your doctor. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Effective in controlling various types of seizures.
• Extended-release formulation allows for once-daily dosing.
• Generally well-tolerated with fewer cognitive side effects.
• Minimal drug-drug interactions compared to other AEDs.
• Can be used as monotherapy or adjunctive therapy.
• Improves patient adherence due to simplified regimen.

Side Effects

• Somnolence (drowsiness)
• Asthenia (weakness)
• Dizziness
• Headache
• Irritability
• Nervousness
• Anorexia (loss of appetite)
• Infection (e.g., nasopharyngitis)
• Diarrhea
• Nausea
• Behavioral changes (e.g., aggression, agitation)
• Coordination difficulties

Safety Measures

• Alcohol - Avoid alcohol as it can increase central nervous system depression, leading to enhanced drowsiness and dizziness.
• Pregnancy - Use only if the potential benefit outweighs the risk to the fetus. Consult a doctor, as antiepileptic drugs carry potential risks.
• Breastfeeding - Levetiracetam is excreted into breast milk. Consult a healthcare professional to weigh risks versus benefits for the infant.
• Liver - Generally does not require dose adjustment in hepatic impairment, but caution is advised in severe cases.
• Kidney - Dosage adjustment is typically required in patients with renal impairment due to renal excretion of the drug.
• Lung - Generally safe for use in patients with lung conditions, but monitor for any signs of respiratory depression if used with other CNS depressants.

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