GANATON TOTAL 10

About

Itopride, widely recognized by brand names such as Ganaton, is a highly effective prokinetic agent specifically designed to enhance and restore normal gastrointestinal motility. Its distinctive dual mechanism of action involves both dopamine D2 receptor antagonism and acetylcholinesterase inhibition. By blocking dopamine D2 receptors, it counteracts the inhibitory effects of dopamine on acetylcholine release within the enteric nervous system. Concurrently, by inhibiting acetylcholinesterase, it prevents the breakdown of acetylcholine, thereby increasing its concentration in the synaptic cleft. This combined pharmacological effect significantly boosts acetylcholine levels, leading to enhanced gastric emptying, improved coordination of gastrointestinal contractions, and accelerated transit of food through the digestive tract. Itopride is primarily indicated for the symptomatic treatment of functional dyspepsia, a common disorder characterized by chronic or recurrent upper abdominal pain or discomfort. It effectively alleviates associated symptoms such as bloating, early satiety, nausea, vomiting, and abdominal discomfort, thereby improving the overall quality of life for patients suffering from impaired gastrointestinal motility.

Uses

• Functional Dyspepsia
• Non-ulcer dyspepsia
• Gastroparesis
• Symptoms of bloating and early satiety

Directions For Use

Take before meals, usually three times a day, or as directed by your doctor. Swallow whole with water.

Benefits

• Enhances gastric emptying.
• Relieves bloating and abdominal discomfort.
• Reduces nausea and vomiting.
• Improves symptoms of early satiety.
• Restores normal gastrointestinal motility.
• Well-tolerated with a low incidence of central nervous system side effects.

Side Effects

• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Nausea
• Constipation
• Increased salivation
• Rash
• Tremor
• Galactorrhea (rare)
• Gynecomastia (rare)
• Leukopenia (rare)

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol may irritate the stomach and worsen GI symptoms.
• Pregnancy - Use only if clearly indicated and potential benefits outweigh risks; consult a doctor.
• Breastfeeding - Not recommended as it may be excreted in breast milk.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be considered.
• Kidney - Use with caution in patients with kidney impairment; dose adjustment may be considered.
• Lung - No specific contraindications or precautions related to lung conditions.

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