GRAFNOS-1MG 10'S

About

Grafnos-1mg contains tacrolimus, a potent immunosuppressant belonging to the calcineurin inhibitor class. It is primarily used to prevent organ rejection in patients who have received kidney, liver, or heart transplants. Tacrolimus works by inhibiting the activity of calcineurin, an enzyme crucial for the activation of T-lymphocytes, which are key components of the immune system responsible for recognizing and attacking foreign tissues. By suppressing T-cell activation, tacrolimus effectively reduces the body's immune response against the transplanted organ, thereby preventing rejection. Due to its narrow therapeutic index, careful monitoring of blood levels is essential to ensure efficacy and minimize toxicity. It is a cornerstone therapy in transplant medicine.

Uses

• Prevention of organ rejection in kidney transplant recipients.
• Prevention of organ rejection in liver transplant recipients.
• Prevention of organ rejection in heart transplant recipients.
• Treatment of certain autoimmune diseases (off-label use).

Directions For Use

Take orally twice daily, on an empty stomach, as prescribed by your transplant physician. Do not miss doses.

Benefits

• Highly effective in preventing organ transplant rejection.
• Crucial for long-term transplant success.
• Reduces the risk of immune-mediated damage to the transplanted organ.
• Allows patients to maintain their transplanted organ.
• Available in various formulations for tailored therapy.
• A cornerstone of modern immunosuppressive regimens.

Side Effects

• Nephrotoxicity (kidney damage)
• Neurotoxicity (tremor, headache)
• Hyperglycemia (high blood sugar)
• Hypertension (high blood pressure)
• Gastrointestinal disturbances (nausea, diarrhea)
• Infections (due to immunosuppression)
• Hyperkalemia (high potassium)
• Insomnia
• Anemia
• Peripheral edema
• Alopecia
• Malignancy risk (lymphoma)

Safety Measures

• Alcohol - Avoid alcohol as it can increase the risk of liver toxicity and other side effects.
• Pregnancy - Tacrolimus can cause fetal harm; use only if benefits outweigh risks, with careful monitoring.
• Breastfeeding - Tacrolimus is excreted in breast milk; breastfeeding is generally not recommended due to potential infant exposure.
• Liver - Use with extreme caution in patients with liver impairment; dosage adjustments are often necessary, and monitoring is critical.
• Kidney - Tacrolimus is nephrotoxic; careful monitoring of renal function and drug levels is essential.
• Lung - Can cause interstitial lung disease as a rare but serious side effect; monitor for respiratory symptoms.

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