I-Dox 20mg Injection

About

I-Dox 20mg Injection, containing Doxorubicin, is a cornerstone anthracycline cytotoxic antibiotic widely employed in the treatment of a broad spectrum of cancers. Its potent anticancer effects are primarily mediated through three distinct mechanisms: intercalation into DNA, which disrupts its structure and function; inhibition of topoisomerase II, an enzyme critical for DNA replication and repair; and the generation of highly reactive free radicals, leading to oxidative damage to cellular components. These combined actions result in significant DNA damage, inhibition of both DNA and RNA synthesis, and ultimately, programmed cell death (apoptosis) in rapidly proliferating cancer cells. Doxorubicin is effective against various solid tumors and hematological malignancies, but its administration necessitates careful monitoring due to the risk of dose-dependent cardiotoxicity and myelosuppression.

Uses

• Breast cancer
• Lymphomas (Hodgkin's, non-Hodgkin's)
• Leukemias
• Sarcomas

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are carefully calculated based on body surface area and clinical condition.

Benefits

• Broad-spectrum anticancer activity
• Effective in various solid tumors
• Key component in many chemotherapy regimens
• Induces apoptosis in cancer cells
• Established efficacy in hematological cancers
• Potent cytotoxic agent

Side Effects

• Cardiotoxicity (dose-dependent)
• Myelosuppression
• Nausea
• Vomiting
• Alopecia
• Stomatitis
• Diarrhea
• Red urine (harmless)
• Injection site reactions (extravasation risk)
• Fatigue
• Anorexia
• Secondary malignancies (rare)

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated in pregnancy due to severe teratogenic and embryotoxic potential. Use effective contraception.
• Breastfeeding - Contraindicated during breastfeeding due to potential for serious adverse effects in the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose reductions are often necessary. Monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary. Monitor kidney function closely.
• Lung - While not a primary target, monitor for any signs of pulmonary toxicity, especially in patients receiving other lung-toxic agents.

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