IMDUR 60MG TAB 30's

About

Isosorbide mononitrate is a long-acting nitrate used for the prevention of angina pectoris (chest pain) due to coronary artery disease. It is an active metabolite of isosorbide dinitrate and works by releasing nitric oxide (NO) in vascular smooth muscle. Nitric oxide activates guanylate cyclase, leading to an increase in cyclic GMP (cGMP), which ultimately results in dephosphorylation of myosin light chains and relaxation of smooth muscle cells. This causes vasodilation of both arteries and veins, with a predominant effect on veins, leading to decreased preload (reduced venous return to the heart) and, to a lesser extent, decreased afterload.

This reduction in cardiac workload and improved coronary blood flow helps to alleviate and prevent anginal attacks. Isosorbide mononitrate is particularly useful for patients requiring sustained nitrate therapy to manage chronic stable angina, providing a consistent therapeutic effect throughout the day. It is not intended for the acute relief of angina attacks, for which rapidly acting nitrates are preferred.

Uses

• Prophylaxis of angina pectoris due to coronary artery disease.
• Long-term management of stable angina.
• Reduction of frequency and severity of anginal attacks.
• Used in patients who cannot tolerate or respond to beta-blockers or calcium channel blockers.

Directions For Use

Take once daily in the morning, as prescribed by your doctor. Swallow the tablet whole.

Benefits

• Effectively prevents anginal attacks.
• Reduces the frequency and severity of chest pain.
• Improves exercise tolerance in patients with angina.
• Provides sustained relief from angina symptoms.
• Helps to reduce the heart's workload.
• Improves blood flow to the heart muscle.

Side Effects

• Headache (often severe, especially initially)
• Dizziness
• Hypotension (low blood pressure)
• Nausea
• Flushing
• Tachycardia (fast heart rate)
• Weakness
• Syncope (fainting)
• Rash
• Vomiting
• Diarrhea
• Orthostatic hypotension

Safety Measures

• Alcohol - Alcohol can enhance the hypotensive effects of isosorbide mononitrate, leading to severe dizziness or fainting. Avoid or limit alcohol.
• Pregnancy - Isosorbide mononitrate should be used during pregnancy only if clearly needed and the potential benefit outweighs the risk to the fetus.
• Breastfeeding - It is not known whether isosorbide mononitrate is excreted in human milk. Exercise caution when administered to a nursing mother.
• Liver - Use with caution in patients with severe hepatic impairment, as metabolism may be altered.
• Kidney - No dose adjustment is typically required for renal impairment, but caution is advised in severe cases.
• Lung - Generally safe for use in patients with lung conditions. However, monitor for any unusual respiratory symptoms.

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