Immutal s 360

About

Immutal S 360, containing mycophenolate mofetil, is a potent immunosuppressant primarily utilized to prevent organ rejection in patients who have undergone solid organ transplantation, such as kidney, heart, or liver transplants. It functions by selectively inhibiting inosine monophosphate dehydrogenase, an enzyme crucial for the de novo synthesis of guanosine nucleotides. This mechanism specifically targets and suppresses the proliferation of T and B lymphocytes, which are key immune cells responsible for mediating transplant rejection. By dampening the immune response, it helps the body accept the new organ.

This medication is typically used in combination with other immunosuppressive agents, including corticosteroids and calcineurin inhibitors, to achieve optimal immunosuppression and minimize the risk of acute and chronic rejection episodes. Careful monitoring of drug levels, renal function, and hematological parameters is essential throughout therapy to ensure efficacy and manage potential adverse effects. Dosage adjustments may be necessary based on individual patient response and tolerability.

Uses

• Prevention of organ rejection in kidney transplant patients.
• Prevention of organ rejection in heart transplant patients.
• Prevention of organ rejection in liver transplant patients.
• Treatment of certain autoimmune diseases (off-label use).

Directions For Use

Take orally as directed by your physician, usually twice daily. Do not crush or chew tablets.

Benefits

• Effective in preventing acute organ rejection.
• Reduces the risk of chronic allograft nephropathy.
• Allows for reduction in calcineurin inhibitor doses.
• Improves long-term graft survival rates.
• Available in various formulations for flexibility.
• Well-established safety profile in transplant settings.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia
• Thrombocytopenia (low platelet count)
• Increased risk of infections
• Increased risk of lymphoma and other malignancies
• Hypertension
• Hyperglycemia
• Headache

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects and potentially interact with the medication.
• Pregnancy - Contraindicated in pregnancy due to significant teratogenic risk. Effective contraception is mandatory for women of childbearing potential.
• Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with severe chronic kidney disease; dose adjustments may be required.
• Lung - No specific contraindications, but monitor for opportunistic infections which may affect the lungs.

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