Jaknat 5mg Tablet

About

Jaknat 5mg Tablet contains a Janus kinase (JAK) inhibitor, a targeted synthetic disease-modifying anti-rheumatic drug (tsDMARD). It works by selectively inhibiting the activity of specific JAK enzymes, which are crucial in the signaling pathways of various cytokines and growth factors involved in inflammation and immune responses. By blocking these pathways, Jaknat helps to reduce inflammation, alleviate pain, and prevent joint damage in chronic autoimmune conditions. This mechanism offers a different approach compared to traditional DMARDs and biologics, targeting intracellular signaling.

Administered orally, Jaknat is typically used when other treatments, such as methotrexate or TNF inhibitors, have been ineffective or poorly tolerated. Before starting treatment, patients are usually screened for tuberculosis and viral infections, and vaccinations may be recommended. Regular monitoring for potential side effects, including infections, blood count changes, and lipid abnormalities, is essential throughout the treatment period to ensure patient safety and optimize therapeutic outcomes.

Uses

• Treatment of moderate to severe rheumatoid arthritis.
• Management of psoriatic arthritis.
• Treatment of ulcerative colitis.
• Management of ankylosing spondylitis.

Directions For Use

Take orally with or without food, as directed by your doctor. Do not crush, split, or chew the tablet.

Benefits

• Reduces inflammation and pain effectively.
• Slows progression of joint damage.
• Improves physical function and quality of life.
• Oral administration offers convenience.
• Effective in patients who failed other therapies.
• Targeted mechanism of action.

Side Effects

• Upper respiratory tract infections
• Headache
• Diarrhea
• Nausea
• Nasopharyngitis
• Increased risk of serious infections (e.g., herpes zoster)
• Elevated cholesterol levels
• Anemia
• Lymphopenia
• Neutropenia
• Increased risk of thrombosis (DVT, PE)
• Elevated liver enzymes

Safety Measures

• Alcohol - No direct interaction, but excessive alcohol may exacerbate underlying conditions or liver issues.
• Pregnancy - Not recommended; animal studies show reproductive toxicity. Use effective contraception during and for at least 4 weeks after treatment.
• Breastfeeding - Not recommended; it is unknown if it passes into breast milk. Discontinue breastfeeding during treatment.
• Liver - Use with caution in patients with moderate to severe hepatic impairment; dose adjustment may be necessary.
• Kidney - Dose adjustment is required in patients with moderate to severe renal impairment.
• Lung - Increased risk of respiratory infections, including tuberculosis; screen for latent TB before starting treatment.

Disclaimer

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