About
Finerenone is a non-steroidal mineralocorticoid receptor (MR) antagonist indicated for reducing the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, non-fatal myocardial infarction, and hospitalization for heart failure. It is specifically prescribed for adult patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D). Finerenone works by selectively blocking overactivated MRs, which are known to contribute to inflammation and fibrosis in the kidneys and heart, key drivers of CKD progression and cardiovascular complications in T2D.
Unlike traditional steroidal MR antagonists, finerenone exhibits a more selective binding profile and does not significantly cross the blood-brain barrier, potentially leading to a reduced incidence of steroid-related side effects. Its targeted action helps to mitigate the progression of kidney damage and cardiovascular complications by addressing the underlying pathophysiological mechanisms driven by MR overactivation. This makes finerenone a crucial therapeutic option, offering a new approach to protect both kidney and heart health beyond conventional treatments and improving long-term outcomes for this high-risk patient population.
Uses
- Reduces risk of sustained eGFR decline in CKD.
- Reduces risk of end-stage kidney disease.
- Reduces risk of cardiovascular death.
- Reduces risk of non-fatal myocardial infarction.
Directions For Use
Take once daily with or without food. Do not take with grapefruit or grapefruit juice.
Benefits
- Protects kidney function in CKD/T2D.
- Reduces risk of cardiovascular events.
- Non-steroidal MR antagonist.
- Targets inflammation and fibrosis.
- Once-daily oral administration.
- Improves long-term outcomes for high-risk patients.
Side Effects
- Hyperkalemia (high potassium levels)
- Hypotension (low blood pressure)
- Hyponatremia (low sodium levels)
- Dizziness
- Nausea
- Fatigue
- Diarrhea
- Increased uric acid
- Decreased eGFR (transient)
- Anemia
- Pruritus
- Muscle spasms
Safety Measures
- Alcohol - No specific contraindication, but excessive alcohol can affect liver function, which may indirectly impact drug metabolism.
- Pregnancy - Not recommended during pregnancy due to potential for adverse effects on fetal development.
- Breastfeeding - Not recommended during breastfeeding as it is unknown if finerenone is excreted in human milk.
- Liver - Use with caution in patients with moderate hepatic impairment; not recommended in severe hepatic impairment.
- Kidney - Contraindicated in patients with severe renal impairment (eGFR <15 mL/min/1.73 m²) or end-stage renal disease.
- Lung - Generally safe, no specific lung-related precautions for finerenone.
Disclaimer
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