KOMBIGLYZE XR5MG/1000 1/7

About

KOMBIGLYZE XR 5mg/1000mg is an extended-release combination medication containing saxagliptin and metformin, used for the treatment of type 2 diabetes mellitus. Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of active incretin hormones (GLP-1 and GIP), which in turn enhance glucose-dependent insulin secretion and suppress glucagon release. Metformin, a biguanide, primarily reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity.

This medication is indicated for adults with type 2 diabetes as an adjunct to diet and exercise, particularly when glycemic control is not adequately achieved with metformin alone or other antidiabetic agents. The combination of these two agents provides complementary mechanisms of action to improve both fasting and postprandial blood glucose levels, offering a comprehensive approach to managing the disease.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control in adults.
• Used as an adjunct to diet and exercise.
• When monotherapy is insufficient.

Directions For Use

Take this medication orally once daily in the morning with food, as directed by your physician. Swallow the extended-release tablet whole; do not crush, cut, or chew.

Benefits

• Effectively lowers blood glucose levels.
• Improves both fasting and postprandial glucose.
• Enhances insulin sensitivity.
• Reduces hepatic glucose production.
• Provides a dual mechanism of action.
• Generally well-tolerated.

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Nasopharyngitis
• Urinary tract infection
• Hypoglycemia (especially with other agents)
• Lactic acidosis (rare, serious with metformin)
• Pancreatitis (rare)
• Joint pain
• Hypersensitivity reactions
• Vitamin B12 deficiency (long-term metformin use)

Safety Measures

• Alcohol - Excessive alcohol intake should be avoided as it can increase the risk of lactic acidosis, a rare but serious side effect, especially with metformin-containing products.
• Pregnancy - Generally not recommended during pregnancy. Consult a doctor; insulin is often preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Metformin is excreted in breast milk in small amounts; saxagliptin data is limited. Use with caution and under medical supervision, weighing benefits against risks.
• Liver - Use with caution in patients with hepatic impairment. Metformin is contraindicated in severe liver disease due to increased risk of lactic acidosis.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is required for moderate impairment due to metformin accumulation risk.
• Lung - No specific contraindications related to lung conditions, but severe respiratory failure can increase lactic acidosis risk due to hypoxia.

Disclaimer

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