Lipodox 10mg Injection

About

Doxorubicin liposomal is an anthracycline topoisomerase II inhibitor, a potent chemotherapeutic agent used in the treatment of various cancers. Encapsulation in liposomes significantly alters its pharmacokinetic profile, leading to a prolonged circulation time in the bloodstream and preferential accumulation in tumor tissues. This enhanced permeability and retention (EPR) effect helps to deliver the drug more effectively to cancerous cells while minimizing exposure to healthy tissues. The formulation aims to reduce systemic toxicities, particularly cardiotoxicity and myelosuppression, which are common with conventional doxorubicin, thereby improving the overall safety profile. Its mechanism involves intercalation into DNA, inhibition of topoisomerase II, and generation of free radicals, all contributing to DNA damage and subsequent apoptotic cell death. This targeted approach enhances therapeutic efficacy and patient tolerability.

Uses

• Metastatic ovarian cancer
• AIDS-related Kaposi's sarcoma
• Metastatic breast cancer
• Multiple myeloma (in combination)

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency depend on the specific cancer type and patient's condition.

Benefits

• Targeted drug delivery to tumors
• Reduced cardiotoxicity compared to conventional doxorubicin
• Improved safety profile for certain side effects
• Effective against various solid tumors and hematologic malignancies
• Prolonged circulation time in the body
• Potential for better patient tolerability

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Stomatitis/mucositis
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Alopecia (hair loss)
• Fatigue
• Diarrhea or constipation
• Infusion-related reactions
• Cardiac dysfunction (less common than conventional doxorubicin)
• Skin discoloration
• Anorexia
• Peripheral neuropathy

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate side effects or interact with the medication.
• Pregnancy - Contraindicated in pregnancy due to severe fetal harm risk. Effective contraception is essential.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with renal impairment; monitoring is advised.
• Lung - Monitor for pulmonary toxicity, though less common; report any respiratory symptoms.

Disclaimer

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