Lipodox 20mg Injection

About

Lipodox 20mg Injection contains doxorubicin hydrochloride in a pegylated liposomal formulation, designed to prolong circulation time and enhance tumor accumulation while reducing cardiotoxicity and other systemic side effects associated with conventional doxorubicin. This advanced delivery system allows for targeted drug release within tumor tissues, improving the therapeutic index. It is an anthracycline antibiotic that intercalates DNA, inhibits topoisomerase II, and generates free radicals, leading to cell death. Its mechanism of action makes it effective against rapidly proliferating cells, a hallmark of many cancers. The liposomal encapsulation helps to protect the drug from degradation and reduces its distribution to healthy tissues, particularly the heart.

Uses

• Treatment of AIDS-related Kaposi's sarcoma.
• Management of metastatic ovarian cancer.
• Therapy for multiple myeloma in combination with bortezomib.
• Treatment of metastatic breast cancer.

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency are determined by the physician based on the specific cancer type and patient's condition.

Benefits

• Reduced cardiotoxicity compared to conventional doxorubicin.
• Prolonged circulation time in the bloodstream.
• Enhanced accumulation in tumor tissues.
• Improved safety profile for certain patient populations.
• Effective against various solid tumors and hematologic malignancies.
• Minimizes exposure to healthy tissues.

Side Effects

• Nausea and vomiting
• Stomatitis/mucositis
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Alopecia (hair loss)
• Myelosuppression (low blood counts)
• Fatigue and weakness
• Diarrhea or constipation
• Anorexia (loss of appetite)
• Infusion-related reactions
• Skin discoloration
• Peripheral neuropathy
• Cardiac dysfunction (less common than with conventional doxorubicin)

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment as it may exacerbate side effects or interact with the medication.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus. Effective contraception should be used.
• Breastfeeding - Breastfeeding is contraindicated during treatment and for a period after the last dose due to drug excretion into breast milk.
• Liver - Use with caution in patients with impaired liver function; dose adjustments may be necessary.
• Kidney - Generally safe in patients with mild to moderate renal impairment; severe impairment may require dose modification.
• Lung - Monitor for signs of pulmonary toxicity, though less common than with other chemotherapies.

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