LUPRIDE DEPOT 3.75 INJ 1VIAL

About

LUPRIDE DEPOT 3.75 INJ contains leuprolide acetate, a synthetic gonadotropin-releasing hormone (GnRH) agonist. Upon initial administration, it transiently stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continuous and prolonged administration, it leads to a profound desensitization and downregulation of pituitary GnRH receptors. This sustained suppression results in a significant and sustained decrease in LH and FSH secretion, consequently reducing the production of ovarian and testicular steroid hormones, such as estrogen and testosterone, to very low levels. This pharmacological castration effect is therapeutically utilized in the management of various hormone-sensitive conditions, effectively reducing the growth and progression of hormone-dependent tumors or alleviating symptoms associated with excessive sex hormone levels. The depot formulation ensures a sustained release of the active ingredient over an extended period, providing consistent therapeutic effects and simplifying patient adherence.

Uses

• Treatment of advanced prostate cancer
• Management of endometriosis
• Reduction of uterine fibroids
• Treatment of central precocious puberty

Directions For Use

Administer intramuscularly or subcutaneously as a single dose every month, strictly as directed by a healthcare professional.

Benefits

• Effectively suppresses sex hormone levels
• Reduces growth of hormone-sensitive tumors
• Alleviates pain and symptoms of endometriosis
• Helps shrink uterine fibroids
• Delays progression of central precocious puberty
• Provides sustained therapeutic effect with depot formulation

Side Effects

• Hot flashes
• Injection site pain
• Fatigue
• Headache
• Nausea
• Bone pain
• Decreased libido
• Mood changes
• Muscle weakness
• Joint pain
• Weight changes
• Peripheral edema

Safety Measures

• Alcohol - No direct interaction, but alcohol may exacerbate hot flashes in some individuals.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm.
• Breastfeeding - Contraindicated; it is unknown if leuprolide is excreted in human milk.
• Liver - Use with caution in patients with liver impairment; no specific dose adjustment usually needed.
• Kidney - Use with caution in patients with kidney impairment; no specific dose adjustment usually needed.
• Lung - No direct impact on lung function, but monitor for any rare respiratory issues.

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