MEROART 1.0GM ING 1

About

Meroart 1.0GM Injection, containing meropenem, is a broad-spectrum carbapenem antibiotic used to treat a wide range of severe bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Meropenem is highly effective against both Gram-positive and Gram-negative bacteria, including many anaerobic strains, making it a crucial agent for empirical therapy in critically ill patients or for infections caused by multi-drug resistant organisms.

Its stability against most beta-lactamases further enhances its utility, ensuring efficacy against bacteria that produce these resistance enzymes. Administered intravenously, it achieves high concentrations in various body tissues and fluids, ensuring effective eradication of pathogens in complex infections such as complicated intra-abdominal infections, bacterial meningitis, and severe pneumonia, thereby providing robust antimicrobial coverage.

Uses

• Treatment of complicated intra-abdominal infections.
• Management of bacterial meningitis.
• Treatment of complicated skin and soft tissue infections.
• Empirical therapy for febrile neutropenia.

Directions For Use

Administer intravenously over 15-30 minutes or as an intravenous bolus over 3-5 minutes, as prescribed by a physician.

Benefits

• Broad spectrum of antibacterial activity.
• Effective against multi-drug resistant bacteria.
• Penetrates well into various body tissues.
• Suitable for severe and life-threatening infections.
• Stable against many bacterial beta-lactamases.
• Rapid onset of action via IV administration.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Headache
• Rash
• Injection site reactions (pain, inflammation)
• Thrombophlebitis
• Increased liver enzymes
• Seizures (rare)
• Allergic reactions (anaphylaxis)
• Oral candidiasis
• Clostridium difficile-associated diarrhea

Safety Measures

• Alcohol - No specific interaction with alcohol, but it's generally advisable to avoid alcohol during severe infections.
• Pregnancy - Use only if clearly needed; potential risks should be discussed with a healthcare provider.
• Breastfeeding - Small amounts may pass into breast milk; use with caution and monitor the infant for adverse effects.
• Liver - Use with caution in patients with pre-existing liver disease; monitor liver function tests.
• Kidney - Dosage adjustment is necessary in patients with renal impairment due to renal excretion.
• Lung - Generally safe for lung conditions, often used to treat severe respiratory tract infections.

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