MESAHENZ-400 10

About

Mesalazine, an aminosalicylate, is an anti-inflammatory agent primarily used in the treatment of inflammatory bowel disease (IBD). It works topically within the bowel lumen by inhibiting cyclooxygenase and lipoxygenase pathways, thereby reducing the production of inflammatory mediators such as prostaglandins and leukotrienes. This localized action helps to suppress inflammation in the gastrointestinal tract, particularly in the colon and rectum. Mesalazine is effective in inducing and maintaining remission in patients with mild to moderate ulcerative colitis and can also be used in certain cases of Crohn's disease. Its mechanism of action focuses on modulating the local immune response and reducing oxidative stress in the intestinal mucosa, leading to symptomatic relief and mucosal healing.

The specific dosage, such as 400mg, is tailored to the severity and extent of the disease, as well as the patient's response. It is available in various formulations designed to deliver the active drug to different parts of the intestine, ensuring optimal therapeutic effect where inflammation is most prominent. Regular adherence to the prescribed regimen is crucial for managing chronic IBD and preventing disease flares.

Uses

• Induction and maintenance of remission in mild to moderate ulcerative colitis.
• Treatment of active Crohn's disease, particularly in the colon.
• Prevention of recurrence of ulcerative colitis.
• Management of proctitis and proctosigmoiditis.

Directions For Use

Take as directed by your physician, usually with or after meals. Do not crush or chew extended-release tablets.

Benefits

• Reduces inflammation in the colon and rectum.
• Helps achieve and maintain remission in ulcerative colitis.
• Alleviates symptoms like abdominal pain, diarrhea, and rectal bleeding.
• May reduce the need for corticosteroids in some patients.
• Supports mucosal healing in the gastrointestinal tract.
• Generally well-tolerated with a favorable safety profile.

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Flatulence
• Vomiting
• Rash
• Fever
• Dizziness
• Pancreatitis (rare)
• Myocarditis/Pericarditis (rare)
• Nephrotoxicity (rare, monitor renal function)

Safety Measures

• Alcohol - Alcohol consumption should be moderate. It does not directly interact with mesalazine but may exacerbate gastrointestinal symptoms in IBD patients.
• Pregnancy - Generally considered safe during pregnancy, but use only if clearly needed and under medical supervision. Consult your doctor.
• Breastfeeding - Mesalazine is excreted in breast milk in small amounts. Use with caution and monitor the infant for diarrhea. Consult your doctor.
• Liver - Use with caution in patients with pre-existing liver impairment. Regular monitoring of liver function tests is recommended.
• Kidney - Use with caution in patients with renal impairment. Regular monitoring of renal function is essential, especially during long-term therapy.
• Lung - Rarely, mesalazine can cause hypersensitivity reactions affecting the lungs (e.g., interstitial lung disease). Use with caution in patients with pre-existing lung conditions.

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