Mitomycin 40mg Injection

About

Mitomycin 40mg Injection is a potent antineoplastic antibiotic that operates as an alkylating agent. It functions as a prodrug, which, upon metabolic activation within the body, forms highly reactive intermediates. These intermediates then cross-link DNA strands, leading to irreversible damage to the DNA helix. This critical interference with DNA synthesis and function ultimately inhibits cell division and induces apoptosis, particularly in rapidly proliferating cancer cells. Its unique mechanism of action makes it a valuable component in various cancer treatment protocols. Mitomycin is primarily indicated for the treatment of disseminated adenocarcinoma of the stomach or pancreas, where it can be used systemically. Furthermore, it is effectively utilized intravesically for the management of superficial bladder cancer, preventing recurrence after transurethral resection. It is often employed in combination with other chemotherapeutic agents to enhance its cytotoxic effects and improve therapeutic outcomes.

Uses

• Disseminated adenocarcinoma of the stomach
• Disseminated adenocarcinoma of the pancreas
• Superficial bladder cancer (intravesical)
• Other solid tumors (e.g., breast, lung)

Directions For Use

Administered intravenously or intravesically by a healthcare professional. Dosage and schedule are determined by the physician based on the specific cancer and patient condition.

Benefits

• Effective against various solid tumors.
• Can be used systemically or locally (bladder).
• Well-established in certain adenocarcinoma treatments.
• Induces DNA damage in cancer cells.
• Can be part of combination chemotherapy regimens.
• Helps control tumor growth.

Side Effects

• Myelosuppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Anorexia
• Stomatitis
• Alopecia
• Fever
• Renal toxicity (hemolytic uremic syndrome)
• Pulmonary toxicity (interstitial pneumonitis)
• Extravasation leading to tissue necrosis
• Fatigue
• Diarrhea
• Skin rash

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to severe fetal harm; use effective contraception during and after treatment.
• Breastfeeding - Advise against breastfeeding due to the potential for serious adverse reactions in breastfed infants.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely.
• Kidney - Contraindicated in patients with severe renal impairment due to potential for hemolytic uremic syndrome; monitor kidney function.
• Lung - Monitor for signs of pulmonary toxicity, including interstitial pneumonitis or fibrosis; discontinue if symptoms occur.

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