Mitotax 250mg Injection

About

Paclitaxel is a highly effective antineoplastic agent belonging to the taxane class, widely recognized for its critical role in the treatment of various solid tumors, including ovarian, breast, non-small cell lung cancer, and Kaposi's sarcoma. Its unique mechanism of action involves binding to the beta-tubulin subunit of microtubules, promoting their assembly from tubulin dimers, and crucially, stabilizing them by preventing depolymerization. This stabilization inhibits the normal dynamic reorganization of the microtubule network, which is absolutely essential for vital cellular functions such as cell division, intracellular transport, and maintaining cell shape. Consequently, paclitaxel arrests cancer cells in the G2/M phase of the cell cycle, leading to the induction of apoptosis and ultimately inhibiting tumor growth. Administered intravenously, it undergoes extensive hepatic metabolism, and its efficacy often makes it a cornerstone of combination chemotherapy regimens.

Uses

• Treatment of ovarian cancer.
• Treatment of breast cancer.
• Treatment of non-small cell lung cancer.
• Treatment of Kaposi's sarcoma.

Directions For Use

Administered intravenously, typically over 3 or 24 hours, with dosing frequency varying based on the specific cancer and regimen.

Benefits

• Effective against a broad spectrum of solid tumors.
• Can be used as monotherapy or in combination.
• Improves progression-free survival in many cancers.
• Demonstrates significant tumor response rates.
• Well-established efficacy in metastatic settings.
• Part of standard chemotherapy regimens.

Side Effects

• Myelosuppression (neutropenia)
• Peripheral neuropathy
• Hypersensitivity reactions
• Alopecia
• Nausea and vomiting
• Diarrhea
• Muscle and joint pain
• Bradycardia
• Hypotension
• Mucositis
• Fatigue
• Injection site reactions

Safety Measures

• Alcohol - Avoid alcohol due to potential for liver toxicity and exacerbation of gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnancy due to severe fetal toxicity; use highly effective contraception.
• Breastfeeding - Discontinue breastfeeding as paclitaxel is excreted in breast milk and can harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose reduction is often necessary.
• Kidney - Generally safe in kidney conditions, but monitor renal function, especially with concomitant nephrotoxic drugs.
• Lung - Monitor for pulmonary toxicity (e.g., interstitial pneumonitis), though rare, especially in patients with pre-existing lung disease.

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