NOR METROGYL O SYP 60ML

About

NOR METROGYL O SYP 60ML is a combination antimicrobial medication, typically containing Norfloxacin and Metronidazole or Ornidazole. This synergistic formulation provides broad-spectrum coverage against a wide range of bacterial and protozoal infections, particularly those affecting the gastrointestinal tract. Norfloxacin, a fluoroquinolone antibiotic, inhibits bacterial DNA gyrase, preventing bacterial replication. Metronidazole or Ornidazole, an antiprotozoal and antibacterial agent, disrupts DNA synthesis in susceptible organisms, making it effective against anaerobic bacteria and certain parasites. This dual action ensures comprehensive treatment for mixed infections.

The suspension form is designed for easier administration, especially in pediatric patients or those who have difficulty swallowing tablets. It is rapidly absorbed, reaching therapeutic concentrations in the target tissues to effectively combat the infection. Clinical efficacy has been demonstrated in various infectious conditions, making it a valuable option for managing complex gastrointestinal and other systemic infections where both aerobic and anaerobic pathogens are suspected.

Uses

• Treatment of bacterial and protozoal diarrhea.
• Management of dysentery and other gastrointestinal infections.
• Eradication of certain parasitic infections.
• Prophylaxis in specific surgical procedures.

Directions For Use

Shake the bottle well before each use. Administer the prescribed dose orally, usually with or after food to minimize gastrointestinal upset.

Benefits

• Provides broad-spectrum antimicrobial coverage.
• Effective against both bacterial and protozoal pathogens.
• Convenient oral suspension for easy administration.
• Targets common gastrointestinal infections effectively.
• Reduces the risk of resistance development with combination therapy.
• Offers rapid symptomatic relief in many cases.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Metallic taste in mouth
• Darkening of urine
• Skin rash
• Peripheral neuropathy (rare)
• Seizures (rare)
• Tendinitis/Tendon rupture (rare, with fluoroquinolones)

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment and for at least 48-72 hours after the last dose, as it may cause a disulfiram-like reaction (nausea, vomiting, flushing, headache).
• Pregnancy - Generally not recommended during pregnancy, especially in the first trimester. Consult your doctor to weigh the potential benefits against risks.
• Breastfeeding - Excreted into breast milk. Consult your doctor; breastfeeding may need to be temporarily discontinued or an alternative medication considered.
• Liver - Use with caution in patients with severe liver disease. Dose adjustment may be necessary. Regular monitoring of liver function tests is advised.
• Kidney - Use with caution in patients with kidney impairment. Dose adjustment may be required based on creatinine clearance.
• Lung - Generally safe for use in patients with lung conditions, but caution is advised in those with severe respiratory insufficiency or pre-existing neurological disorders.

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