OBETOHEP 10MG

About

Obeticholic acid is a synthetic bile acid and a potent agonist of the farnesoid X receptor (FXR), a nuclear receptor predominantly expressed in the liver and intestine. It is specifically indicated for the treatment of primary biliary cholangitis (PBC) in adults, either in combination with ursodeoxycholic acid (UDCA) for patients with an inadequate response to UDCA, or as monotherapy for those unable to tolerate UDCA. By activating FXR, obeticholic acid plays a crucial role in regulating bile acid synthesis, transport, and metabolism. This activation leads to a reduction in the hepatic synthesis of bile acids and an increase in their excretion, thereby mitigating the accumulation of potentially toxic bile acids in the liver. This action helps to reduce liver inflammation and fibrosis, slowing the progression of PBC and improving biochemical markers of liver function, offering a vital therapeutic option for managing this chronic cholestatic liver disease.

Uses

• Treatment of primary biliary cholangitis (PBC).
• Used in combination with ursodeoxycholic acid (UDCA).
• Monotherapy for PBC in UDCA-intolerant patients.
• Reduces elevated alkaline phosphatase levels in PBC.

Directions For Use

Take orally once daily with or without food, as prescribed by your doctor. Do not exceed the recommended dose.

Benefits

• Effective in treating primary biliary cholangitis.
• Reduces liver inflammation and damage.
• Improves biochemical markers of liver function.
• Offers an alternative for UDCA-intolerant patients.
• Helps slow disease progression.
• Can be used in combination therapy.

Side Effects

• Pruritus (itching)
• Fatigue
• Abdominal pain
• Constipation
• Diarrhea
• Nausea
• Oropharyngeal pain
• Dizziness
• Eczema
• Thyroid function abnormalities
• Peripheral edema
• Urinary tract infection

Safety Measures

• Alcohol - Alcohol can worsen liver disease; avoid or limit consumption while on obeticholic acid.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus; consult a doctor.
• Breastfeeding - It is unknown if obeticholic acid is excreted in human milk; caution is advised, and a doctor should be consulted.
• Liver - Contraindicated in patients with complete biliary obstruction. Dose adjustment is required for moderate to severe hepatic impairment.
• Kidney - No specific dose adjustment is recommended for patients with renal impairment.
• Lung - No specific precautions for lung conditions; general monitoring is advised.

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