Onco BCG 40mg Injection

About

Onco BCG Injection contains attenuated live bacteria of Mycobacterium bovis, known as Bacillus Calmette-Guérin (BCG). It is primarily used as an immunotherapy for non-muscle invasive bladder cancer (NMIBC), including carcinoma in situ. When instilled directly into the bladder, BCG triggers a robust localized immune response, stimulating the body's immune cells, such as macrophages, natural killer cells, and T-lymphocytes, to infiltrate the bladder wall. This complex immunomodulatory action leads to the destruction of cancer cells lining the bladder and helps prevent recurrence and progression of superficial bladder tumors. BCG therapy is a well-established and highly effective treatment option for high-risk NMIBC, often administered after transurethral resection of bladder tumor (TURBT) to significantly reduce the risk of disease recurrence and progression, thereby improving long-term outcomes for patients.

Uses

• Non-muscle invasive bladder cancer (intravesical therapy)
• Carcinoma in situ of the bladder
• Prevention of recurrence of superficial bladder tumors
• Adjuvant therapy after transurethral resection of bladder tumor (TURBT)

Directions For Use

Administered intravesically (into the bladder) by a healthcare professional. The treatment involves a series of instillations.

Benefits

• Effective immunotherapy for bladder cancer
• Reduces recurrence rates of superficial tumors
• May prevent progression to invasive cancer
• Avoids systemic chemotherapy side effects
• Well-tolerated localized treatment
• Established standard of care for specific bladder cancers

Side Effects

• Bladder irritation (cystitis)
• Frequent urination
• Urgency to urinate
• Hematuria (blood in urine)
• Fever and chills
• Flu-like symptoms
• Fatigue
• Joint pain (arthralgia)
• Skin rash
• Prostatitis (inflammation of prostate)
• Epididymitis (inflammation of epididymis)
• BCG-osis (systemic infection, rare but serious)

Safety Measures

• Alcohol - No specific contraindication with alcohol, but it's generally advisable to avoid excessive alcohol during treatment to support overall health.
• Pregnancy - Contraindicated in pregnancy due to potential risk to the fetus. Effective contraception is recommended during treatment.
• Breastfeeding - Not recommended during breastfeeding due to potential systemic absorption and unknown effects on the infant.
• Liver - Use with caution in patients with severe liver impairment, especially if systemic BCG infection is suspected, as it may complicate management.
• Kidney - Use with caution in patients with severe kidney impairment, particularly if there's a risk of systemic absorption or infection.
• Lung - Rarely, systemic BCG infection can lead to pulmonary involvement (BCG pneumonitis). Monitor for new or worsening respiratory symptoms.

Disclaimer

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