ONGLYZA-5 MG 10

About

Onglyza-5 MG contains saxagliptin, an advanced oral antidiabetic medication belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. This medication works by enhancing the body's natural ability to control blood glucose levels by inhibiting the enzyme DPP-4. DPP-4 is responsible for the rapid inactivation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are released from the gut in response to food. By preserving the active forms of these incretin hormones, saxagliptin increases insulin synthesis and release from pancreatic beta cells in a glucose-dependent manner, and simultaneously reduces glucagon secretion from pancreatic alpha cells. This dual action effectively lowers both fasting and post-meal blood glucose concentrations in patients with type 2 diabetes mellitus. It is typically used as an adjunct to diet and exercise, either as monotherapy when metformin is inappropriate or in combination with other antidiabetic agents to achieve optimal glycemic control.

Uses

• Treatment of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• As monotherapy when metformin is inappropriate.
• In combination with other antidiabetic agents.

Directions For Use

Take once daily, with or without food, as directed by your healthcare provider. Swallow the tablet whole with water.

Benefits

• Effectively lowers blood glucose and HbA1c.
• Low risk of hypoglycemia when used alone.
• Well-tolerated with a generally favorable safety profile.
• Can be used as monotherapy or in combination.
• Does not typically cause weight gain.
• Improves pancreatic beta-cell function.

Side Effects

• Upper respiratory tract infection.
• Urinary tract infection.
• Headache.
• Nasopharyngitis.
• Sinusitis.
• Diarrhea.
• Nausea.
• Abdominal pain.
• Joint pain.
• Peripheral edema.
• Pancreatitis (rare).
• Hypersensitivity reactions (rash, hives).

Safety Measures

• Alcohol - No specific contraindication with alcohol, but excessive intake should be avoided as it can affect blood glucose levels.
• Pregnancy - Not recommended during pregnancy; consult a doctor to discuss alternative treatments for gestational diabetes or pre-existing diabetes.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk; consult a healthcare professional.
• Liver - Use with caution in patients with moderate to severe liver impairment; dose adjustment may be necessary.
• Kidney - Dose adjustment is required for patients with moderate to severe kidney impairment (eGFR <45 mL/min/1.73m²).
• Lung - No specific lung-related contraindications; however, monitor for any unusual respiratory symptoms.

Disclaimer

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