PANGRAF 0.25

About

PANGRAF 0.25 contains Tacrolimus, a potent calcineurin inhibitor widely used as an immunosuppressant medication. Its primary function is to prevent organ rejection in patients who have undergone organ transplantation, such as kidney, liver, or heart transplants. Tacrolimus works by suppressing the immune system's T-cell activity, which is responsible for recognizing and attacking the transplanted organ as foreign. By modulating this immune response, it significantly reduces the risk of the body rejecting the new organ.

Due to its narrow therapeutic index, careful monitoring of blood levels is essential to ensure efficacy and minimize adverse effects. The 0.25mg dosage allows for precise titration, particularly in pediatric patients or those requiring very fine dose adjustments. It is a critical component of long-term immunosuppressive regimens, often used in combination with other medications to achieve optimal outcomes post-transplant.

Uses

• Prevention of organ transplant rejection (kidney, liver, heart)
• Treatment of acute organ rejection episodes
• Management of severe atopic dermatitis (topical formulations)
• Treatment of other autoimmune conditions as prescribed

Directions For Use

Take exactly as prescribed by your physician, usually twice daily, on an empty stomach for consistent absorption. Do not crush or chew the tablet.

Benefits

• Effectively prevents organ transplant rejection
• Significantly prolongs transplanted organ survival
• Reduces the need for higher doses of other immunosuppressants
• Improves the quality of life for transplant recipients
• Available in precise low doses for titration
• Effective across various types of organ transplants

Side Effects

• Nephrotoxicity (kidney damage)
• Neurotoxicity (tremor, headache)
• Hypertension (high blood pressure)
• Hyperglycemia (high blood sugar)
• Hyperkalemia (high potassium levels)
• Gastrointestinal disturbances (nausea, diarrhea)
• Increased risk of infections
• Increased risk of malignancy (lymphoma, skin cancer)
• Alopecia (hair loss)
• Insomnia
• Anemia
• Peripheral edema

Safety Measures

• Alcohol - Avoid alcohol consumption as it can increase the risk of liver toxicity and other side effects, and may interfere with tacrolimus metabolism.
• Pregnancy - Contraindicated during pregnancy unless the potential benefits outweigh the risks. Tacrolimus can cause fetal harm. Effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding as tacrolimus passes into breast milk and can cause serious adverse effects in the infant.
• Liver - Use with extreme caution in patients with liver conditions. Dose adjustment is often required due to hepatic metabolism; monitor liver function closely.
• Kidney - A major side effect is nephrotoxicity. Requires close and regular monitoring of kidney function (creatinine, GFR) to prevent or manage kidney damage.
• Lung - No direct contraindication, but patients on immunosuppressants like tacrolimus have an increased risk of opportunistic lung infections.

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