About
This medication is a fixed-dose combination product containing Gabapentin and Nortriptyline, formulated to provide comprehensive relief for chronic neuropathic pain. Gabapentin, an anticonvulsant and neuropathic pain agent, primarily functions by binding to the alpha-2-delta subunit of voltage-gated calcium channels, which leads to a reduction in the release of excitatory neurotransmitters and modulates overactive nerve signals. Nortriptyline, a tricyclic antidepressant (TCA), exerts its therapeutic effects by inhibiting the reuptake of norepinephrine and, to a lesser extent, serotonin in the brain, thereby increasing the concentrations of these neurotransmitters in the synaptic cleft. This dual mechanism of action offers synergistic benefits, addressing both the direct nerve pain component and the often-associated mood disturbances in chronic pain conditions. The combination is particularly effective for managing conditions such as diabetic neuropathy and postherpetic neuralgia, improving overall pain control and patient quality of life.
Uses
- Management of chronic neuropathic pain.
- Treatment of diabetic neuropathy.
- Relief of postherpetic neuralgia.
- Adjunctive therapy for certain chronic pain syndromes.
Directions For Use
Take this medication orally, usually once daily at bedtime, with or without food, as directed by your doctor.
Benefits
- Synergistic relief for complex neuropathic pain.
- Addresses both pain and associated mood disturbances.
- Can improve sleep quality.
- Reduces the severity and frequency of pain episodes.
- Well-established efficacy for chronic pain.
- Convenient combination therapy.
Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
- Urinary retention
- Orthostatic hypotension (low blood pressure on standing)
- Nausea
- Headache
- Tremor
- Cardiac arrhythmias (rare, with TCAs)
Safety Measures
- Alcohol - Avoid alcohol as it can significantly increase central nervous system depression and other side effects.
- Pregnancy - Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
- Breastfeeding - Both components pass into breast milk. Use with caution and monitor the infant for adverse effects.
- Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary for both components.
- Kidney - Dose adjustment for gabapentin is necessary in renal impairment. Nortriptyline is primarily metabolized by the liver.
- Lung - Use with caution in patients with severe respiratory depression due to potential for increased sedation.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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