PROSIA PATCH 5 MCG 1'S

About

Prosia Patch (Fentanyl Transdermal System) is a potent opioid analgesic designed for the management of chronic, severe pain that requires continuous, around-the-clock opioid analgesia and for which other treatment options are inadequate. Fentanyl is a synthetic opioid that acts primarily on the mu-opioid receptors in the central nervous system, producing analgesia. The transdermal patch delivers fentanyl systemically through the skin at a controlled rate over a 72-hour period, providing sustained pain relief. This formulation is particularly beneficial for opioid-tolerant patients who require consistent pain management and may have difficulty with oral medications. It is crucial to use this patch strictly as prescribed due to its high potency and potential for serious adverse effects.

Uses

• Management of chronic severe pain.
• Cancer-related pain.
• Neuropathic pain (in selected opioid-tolerant patients).
• Pain requiring continuous opioid analgesia.

Directions For Use

Apply to a clean, dry, non-hairy skin area on the torso or upper arm. Replace every 72 hours.

Benefits

• Provides continuous pain relief for 72 hours.
• Convenient 3-day dosing schedule.
• Avoids the oral route, useful for patients with dysphagia or nausea.
• Maintains stable plasma concentrations of fentanyl.
• Improved quality of life for chronic pain sufferers.
• Effective for opioid-tolerant patients with severe pain.

Side Effects

• Nausea
• Vomiting
• Constipation
• Dizziness
• Drowsiness
• Headache
• Dry mouth
• Sweating
• Pruritus (itching)
• Application site reactions (redness, irritation)
• Respiratory depression
• Confusion

Safety Measures

• Alcohol - Avoid alcohol completely; it significantly increases CNS depression and the risk of respiratory depression.
• Pregnancy - Not recommended; potential for neonatal opioid withdrawal syndrome and respiratory depression in the newborn.
• Breastfeeding - Not recommended; excreted in breast milk and can cause serious adverse effects, including respiratory depression, in the infant.
• Liver - Use with caution; dose reduction may be needed in patients with hepatic impairment due to reduced metabolism.
• Kidney - Use with caution; dose reduction may be needed in patients with renal impairment due to reduced excretion.
• Lung - Contraindicated in severe respiratory depression or acute/severe bronchial asthma. Monitor closely in patients with chronic obstructive pulmonary disease (COPD).

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