RABLET L 40

About

RABLET L 40 combines Rabeprazole, a proton pump inhibitor (PPI), with Levosulpiride, a prokinetic and antiemetic agent. Rabeprazole works by inhibiting the H+/K+-ATPase enzyme system in gastric parietal cells, leading to a significant reduction in stomach acid production. This action is vital for healing acid-related damage and alleviating symptoms like heartburn. Levosulpiride, a selective dopamine D2 receptor antagonist, enhances gastrointestinal motility by increasing acetylcholine release, thereby accelerating gastric emptying and improving transit. It also has antiemetic properties by blocking dopamine receptors in the chemoreceptor trigger zone. This dual action effectively manages acid-related disorders alongside motility issues, providing comprehensive relief for complex upper digestive conditions.

Uses

• Treatment of gastroesophageal reflux disease (GERD).
• Management of functional dyspepsia.
• Relief from nausea and vomiting associated with gastric motility disorders.
• Healing of peptic ulcers.

Directions For Use

Take orally once daily, preferably before breakfast, as directed by your healthcare provider. Swallow whole, do not chew or crush.

Benefits

• Potently reduces gastric acid secretion.
• Alleviates heartburn and acid reflux symptoms.
• Enhances gastrointestinal motility and emptying.
• Effectively controls nausea and vomiting.
• Provides sustained relief from digestive discomfort.
• Aids in the healing of esophageal erosions and ulcers.

Side Effects

• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Flatulence
• Dry mouth
• Dizziness
• Constipation
• Skin rash
• Extrapyramidal symptoms (Levosulpiride, rare)
• Hyperprolactinemia (Levosulpiride)
• QT prolongation (Levosulpiride, rare)
• Insomnia

Safety Measures

• Alcohol - Alcohol may irritate the stomach lining and potentially worsen symptoms, counteracting the medication's effects. Moderate intake is advised.
• Pregnancy - Use with caution during pregnancy. Consult your doctor to weigh the potential benefits against any risks to the fetus.
• Breastfeeding - Levosulpiride passes into breast milk and may affect the infant. Breastfeeding is generally not recommended during treatment.
• Liver - Use with caution in patients with liver impairment. Dosage adjustments may be necessary, especially for Levosulpiride, due to altered metabolism.
• Kidney - Use with caution in patients with severe renal impairment. Dosage adjustments may be required, particularly for Levosulpiride.
• Lung - No direct specific interaction. However, effective management of GERD can reduce the risk of aspiration-related lung complications.

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