About
Mycophenolate mofetil is a prodrug that is rapidly hydrolyzed to its active metabolite, mycophenolic acid (MPA), a potent and selective immunosuppressant. It is widely used in combination with other agents, such as corticosteroids and cyclosporine or tacrolimus, to prevent acute organ rejection in patients undergoing kidney, heart, or liver transplantation. MPA exerts its immunosuppressive effects by reversibly inhibiting inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo pathway of guanosine nucleotide synthesis. Lymphocytes, particularly T and B cells, are critically dependent on this pathway for their proliferation and function. By depleting guanosine nucleotides, mycophenolate mofetil effectively suppresses lymphocyte proliferation, antibody production, and cell-mediated immune responses, thereby helping the body accept the transplanted organ.
Uses
- Prevention of kidney transplant rejection.
- Prevention of heart transplant rejection.
- Prevention of liver transplant rejection.
- Used in combination with other immunosuppressive agents.
Directions For Use
Take this medication orally, usually twice daily, on an empty stomach, exactly as prescribed by your physician. Swallow tablets whole; do not crush or chew.
Benefits
- Highly effective in preventing acute and chronic organ rejection.
- Significantly improves graft and patient survival rates.
- Reduces the incidence of rejection episodes.
- A crucial component of post-transplant immunosuppressive therapy.
- Helps maintain the long-term function of transplanted organs.
- Contributes to an improved quality of life for transplant recipients.
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Leukopenia (low white blood cell count)
- Anemia
- Thrombocytopenia (low platelet count)
- Increased risk of infections
- Headache
- Hypertension
- Tremor
- Increased risk of certain malignancies
Safety Measures
- Alcohol - Limit or avoid alcohol consumption as it may exacerbate gastrointestinal side effects and could potentially interact with the medication.
- Pregnancy - Mycophenolate mofetil is a known human teratogen, causing severe birth defects and miscarriage. It is contraindicated in pregnancy. Women of childbearing potential must use two reliable forms of contraception before, during, and for 6 weeks after treatment.
- Breastfeeding - Mycophenolate mofetil is excreted into breast milk and can cause serious adverse reactions in a nursing infant. Breastfeeding is contraindicated.
- Liver - Use with caution in patients with severe liver impairment. Dose adjustments may be necessary, and liver function should be monitored.
- Kidney - Use with caution in patients with severe chronic kidney impairment. Dose adjustments may be required, and renal function should be closely monitored.
- Lung - Rarely, mycophenolate mofetil has been associated with pulmonary fibrosis or interstitial lung disease. Patients should report any new or worsening respiratory symptoms to their doctor.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!