About
Rifaximin is a non-systemic antibiotic primarily used to treat various gastrointestinal conditions. It works by inhibiting bacterial RNA synthesis, leading to a broad spectrum of antibacterial activity against gut bacteria. What makes rifaximin unique is its minimal absorption into the bloodstream, meaning it acts locally within the intestines, reducing the risk of systemic side effects.
It is particularly effective in targeting bacteria associated with small intestinal bacterial overgrowth (SIBO), traveler's diarrhea caused by non-invasive strains of E. coli, and reducing the risk of overt hepatic encephalopathy recurrence in patients with severe liver disease. By modulating the gut microbiome and reducing ammonia-producing bacteria, rifaximin helps restore microbial balance and alleviate symptoms related to bacterial dysbiosis in the gut.
Uses
- Treatment of small intestinal bacterial overgrowth (SIBO).
- Management of traveler's diarrhea.
- Reduction of hepatic encephalopathy recurrence.
- Treatment of irritable bowel syndrome with diarrhea (IBS-D).
Directions For Use
Take orally with or without food, as directed by your physician. Complete the full course of treatment even if symptoms improve.
Benefits
- Targets gut bacteria with minimal systemic absorption.
- Effective in reducing symptoms of SIBO and IBS-D.
- Prevents recurrence of hepatic encephalopathy.
- Reduces the risk of traveler's diarrhea.
- Generally well-tolerated with a favorable safety profile.
- Helps restore gut microbial balance.
Side Effects
- Nausea
- Abdominal pain
- Diarrhea
- Headache
- Dizziness
- Fatigue
- Peripheral edema
- Flatulence
- Constipation
- Rash
- Muscle spasms
- Urinary tract infection
Safety Measures
- Alcohol - No specific interaction, but alcohol can exacerbate underlying gastrointestinal or liver conditions.
- Pregnancy - Use only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Consult a doctor.
- Breastfeeding - It is unknown if rifaximin is excreted in human milk. Use with caution and consult a healthcare provider.
- Liver - Used in hepatic encephalopathy; however, caution is advised in severe liver impairment.
- Kidney - No dosage adjustment is typically needed for renal impairment due to minimal systemic absorption.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted for this medication.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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