SITAZIT M 50/1000 MG 10S

About

SITAZIT M 50/1000 MG 10S is an oral antidiabetic medication combining Sitagliptin and Metformin, used to improve glycemic control in adults with type 2 diabetes mellitus. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of incretin hormones (GLP-1 and GIP), which in turn stimulate insulin release and decrease glucagon secretion in a glucose-dependent manner. Metformin, a biguanide, primarily reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. This synergistic action helps to lower both fasting and post-meal blood glucose levels, making it an effective option for patients whose diabetes is not adequately controlled by diet, exercise, and either Sitagliptin or Metformin alone.

Uses

• Management of type 2 diabetes mellitus
• Improvement of glycemic control
• Used as an adjunct to diet and exercise
• For patients inadequately controlled on monotherapy

Directions For Use

Take one tablet orally twice daily with meals, or as directed by your healthcare provider. Swallow whole with water.

Benefits

• Lowers both fasting and post-meal glucose
• Improves insulin sensitivity
• Reduces hepatic glucose production
• Glucose-dependent insulin secretion
• Generally well-tolerated
• Convenient fixed-dose combination

Side Effects

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Upper respiratory tract infection
• Hypoglycemia (especially with other agents)
• Pancreatitis (rare)
• Lactic acidosis (rare, with Metformin)
• Vitamin B12 deficiency (long-term Metformin)
• Joint pain (arthralgia)
• Allergic reactions (rash, urticaria)
• Kidney problems (rare, with Metformin)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis with Metformin.
• Pregnancy - Not recommended during pregnancy. Consult a doctor for alternative management of diabetes.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Consult a doctor.
• Liver - Use with caution in mild to moderate liver impairment. Contraindicated in severe liver disease due to Metformin.
• Kidney - Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73m²). Dose adjustment needed for moderate impairment.
• Lung - No direct impact on lung conditions. However, severe respiratory failure can increase lactic acidosis risk.

Disclaimer

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