STILOZ 50 15'S

About

STILOZ 50 contains Cilostazol 50mg, a phosphodiesterase-3 (PDE3) inhibitor primarily used for the symptomatic management of intermittent claudication in patients with peripheral artery disease (PAD). Cilostazol works by inhibiting PDE3, which leads to an increase in intracellular cyclic AMP (cAMP) levels in platelets and vascular smooth muscle cells. This results in potent antiplatelet effects, reducing platelet aggregation, and direct arterial vasodilation, particularly in the femoral circulation. By improving blood flow to the legs and reducing platelet aggregation, Cilostazol helps to alleviate the pain and cramping experienced during exercise, thereby increasing walking distance and improving the quality of life for patients with intermittent claudication. It is a distinct therapeutic agent that addresses both the circulatory and thrombotic aspects of PAD, offering a targeted approach to symptom relief and functional improvement.

Uses

• Symptomatic management of intermittent claudication
• Improving walking distance in patients with peripheral artery disease
• Enhancing quality of life in PAD patients
• Reduction of leg pain and cramping during exercise

Directions For Use

Take orally twice daily, at least 30 minutes before or 2 hours after breakfast and dinner.

Benefits

• Significantly improves maximum and pain-free walking distance
• Reduces symptoms of intermittent claudication
• Enhances overall quality of life for PAD patients
• Possesses both antiplatelet and vasodilatory properties
• Offers a targeted treatment for peripheral artery disease
• May reduce the need for revascularization procedures

Side Effects

• Headache
• Diarrhea or abnormal stools
• Palpitations or tachycardia
• Dizziness
• Nausea or abdominal pain
• Peripheral edema (swelling)
• Rhinitis or pharyngitis
• Dyspepsia (indigestion)
• Ecchymosis (bruising)
• Infection
• Vertigo
• Chest pain

Safety Measures

• Alcohol - Alcohol may increase the risk of dizziness and headache. Use with caution.
• Pregnancy - Not recommended during pregnancy; use only if potential benefit outweighs potential risk to the fetus.
• Breastfeeding - Not recommended; it is unknown if Cilostazol is excreted in breast milk.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be needed.
• Kidney - Use with caution in severe renal impairment; dose adjustment may be needed.
• Lung - Contraindicated in patients with heart failure of any severity due to increased mortality risk.

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