STRONS-500 TAB

About

Strontium Ranelate is an innovative medication used in the treatment of severe osteoporosis, particularly in postmenopausal women and men at high risk of fracture. It possesses a unique dual mechanism of action, simultaneously promoting bone formation and inhibiting bone resorption. This dual effect helps to restore the balance of bone remodeling, leading to an increase in bone mineral density and a significant reduction in the risk of vertebral and non-vertebral fractures.

The active component, strontium, is incorporated into the bone matrix, where it influences osteoblast and osteoclast activity. Its efficacy has been demonstrated in large clinical trials, showing a consistent reduction in fracture incidence across various skeletal sites. The 500mg dosage is typically part of a daily regimen, contributing to long-term bone health and strength.

Uses

• Treatment of severe osteoporosis in postmenopausal women.
• Management of osteoporosis in men at high risk of fracture.
• Reduction of vertebral fracture risk.
• Reduction of non-vertebral fracture risk.

Directions For Use

Dissolve the contents of the sachet in a glass of water and drink immediately, preferably at bedtime, at least two hours after food.

Benefits

• Increases bone mineral density.
• Reduces risk of vertebral fractures.
• Reduces risk of non-vertebral fractures.
• Promotes bone formation.
• Inhibits bone resorption.
• Unique dual mechanism of action.

Side Effects

• Nausea
• Diarrhea
• Headache
• Dermatitis
• Eczema
• Memory impairment
• Seizures (rare)
• Venous thromboembolism (VTE)
• Myocardial infarction (rare)
• Peripheral edema
• Abdominal pain
• Insomnia

Safety Measures

• Alcohol - No specific contraindication with alcohol, but maintaining a healthy lifestyle is important for bone health.
• Pregnancy - Strontium Ranelate is contraindicated during pregnancy due to potential risks to fetal bone development.
• Breastfeeding - Strontium Ranelate is contraindicated during breastfeeding as strontium is excreted in breast milk and could affect the infant.
• Liver - No specific dose adjustment is typically required for liver impairment. However, caution is advised in severe cases.
• Kidney - Contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min). Use with caution in moderate impairment.
• Lung - No specific precautions related to lung conditions.

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