About
Sulpiride is an atypical antipsychotic medication belonging to the benzamide class. It primarily acts as a selective dopamine D2 receptor antagonist in the brain, particularly at lower doses where it can exert antidepressant and anxiolytic effects by blocking presynaptic D2 receptors, leading to increased dopamine turnover. At higher doses, it blocks postsynaptic D2 receptors, which contributes to its antipsychotic properties. Sulpiride is used to treat various psychiatric conditions, including schizophrenia, depressive states, and vertigo. Its unique pharmacological profile allows for a broad range of therapeutic applications, often with a relatively lower incidence of extrapyramidal side effects compared to typical antipsychotics, making it a versatile option in mental health management.
Uses
- Treatment of acute and chronic schizophrenia.
- Management of depressive states.
- Relief from vertigo of various origins.
- Adjunctive therapy for anxiety disorders.
Directions For Use
Take orally, usually two to three times daily, as prescribed by your healthcare provider.
Benefits
- Reduces psychotic symptoms.
- Alleviates depressive moods.
- Effective in treating vertigo.
- May improve social withdrawal.
- Lower risk of certain side effects.
- Can enhance motivation.
Side Effects
- Drowsiness
- Insomnia
- Weight gain
- Increased prolactin levels
- Menstrual disturbances
- Galactorrhea
- Breast enlargement
- Dizziness
- Headache
- Tremor
- Dry mouth
- Constipation
Safety Measures
- Alcohol - Avoid alcohol as it can enhance the sedative effects and increase the risk of adverse reactions.
- Pregnancy - Not recommended, especially during the third trimester, due to potential adverse effects on the neonate. Consult a doctor.
- Breastfeeding - Not advised as sulpiride passes into breast milk and may affect the infant.
- Liver - Use with caution in patients with liver impairment; monitor liver function regularly.
- Kidney - Dosage adjustment is necessary in patients with moderate to severe kidney impairment due to reduced clearance.
- Lung - Generally safe, but caution is advised in patients with severe respiratory depression.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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