Tenecterel 30mg Injection

About

Tenecteplase is a recombinant fibrin-specific thrombolytic agent specifically engineered for the treatment of acute myocardial infarction (AMI), particularly ST-elevation myocardial infarction (STEMI). It functions by binding to fibrin within a thrombus (blood clot) and catalyzing the conversion of plasminogen to plasmin, an enzyme that effectively degrades the fibrin matrix of the clot. Key advantages of tenecteplase include its extended half-life and enhanced fibrin specificity compared to other thrombolytics like alteplase. These properties enable its administration as a single, weight-adjusted intravenous bolus, significantly simplifying the treatment process in emergency situations. This rapid and convenient delivery facilitates swift reperfusion of occluded coronary arteries, which is crucial for limiting myocardial damage, preserving heart function, and ultimately improving patient survival and recovery following a heart attack.

Uses

• Treatment of acute myocardial infarction (heart attack).
• Thrombolytic therapy for ST-elevation myocardial infarction (STEMI).
• Restoration of blood flow in blocked coronary arteries.
• Used within a specific time window after symptom onset.

Directions For Use

Administer as a single intravenous bolus injection, calculated based on body weight, as directed by a healthcare professional.

Benefits

• Rapid and effective clot dissolution.
• Single bolus administration simplifies treatment.
• High fibrin specificity reduces systemic bleeding risk.
• Improves myocardial reperfusion.
• Reduces mortality in acute MI.
• Convenient for emergency use.

Side Effects

• Bleeding (e.g., gastrointestinal, intracranial)
• Hypotension
• Arrhythmias (reperfusion arrhythmias)
• Nausea
• Vomiting
• Fever
• Allergic reactions
• Injection site reactions
• Headache
• Dizziness
• Ecchymosis (bruising)
• Epistaxis (nosebleed)

Safety Measures

• Alcohol - Alcohol consumption is generally discouraged in patients with acute cardiac events; no direct interaction with Tenecteplase.
• Pregnancy - Tenecterel is generally contraindicated in pregnancy due to the risk of maternal and fetal bleeding.
• Breastfeeding - Not recommended during breastfeeding; it is unknown if it passes into breast milk and its effects on the infant.
• Liver - Use with extreme caution in patients with severe liver impairment due to increased risk of bleeding.
• Kidney - No specific dose adjustment for renal impairment, but caution is advised in severe cases due to potential for bleeding complications.
• Lung - No specific contraindications related to lung conditions, but overall patient stability is crucial during administration.

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