TEROZESTA TAB

About

Terozesta Tab contains Letrozole, a potent and highly selective non-steroidal aromatase inhibitor. Its primary mechanism of action involves blocking the enzyme aromatase, which is responsible for the peripheral conversion of anrogens into estrogens in various tissues, particularly in postmenopausal women. By significantly reducing circulating estrogen levels, Letrozole effectively inhibits the growth of hormone receptor-positive breast cancer cells, making it a cornerstone in the treatment of early and advanced breast cancer in postmenopausal women. Beyond oncology, Letrozole is also widely used off-label in reproductive medicine to induce ovulation in anovulatory infertility. In this context, by lowering estrogen, it reduces negative feedback on the pituitary gland, leading to an increase in follicle-stimulating hormone (FSH) release, which stimulates follicular development and ovulation.

Uses

• Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
• Extended adjuvant treatment of hormone receptor-positive breast cancer.
• First-line treatment of hormone receptor-positive advanced breast cancer.
• Ovulation induction in anovulatory infertility (off-label).

Directions For Use

Take the tablet orally with or without food, usually once daily. Follow your doctor's instructions regarding dosage and duration.

Benefits

• Effective in reducing estrogen levels.
• Helps prevent recurrence of breast cancer.
• Can induce ovulation in infertile women.
• Oral administration for convenience.
• Generally well-tolerated in its primary indications.
• Offers a non-steroidal option for aromatase inhibition.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Dizziness
• Bone pain
• Hair thinning
• Sweating
• Weight gain
• Vaginal dryness
• Increased cholesterol levels

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake should be avoided as it may exacerbate some side effects or underlying conditions.
• Pregnancy - Letrozole is contraindicated in pregnancy as it can cause fetal harm. Effective contraception must be used by premenopausal women.
• Breastfeeding - It is not known if letrozole passes into breast milk. Due to potential harm to the infant, breastfeeding is not recommended.
• Liver - Use with caution in patients with severe liver impairment. Dose reduction may be necessary, and liver function should be monitored.
• Kidney - No dose adjustment is typically required for patients with mild to moderate renal impairment. Caution in severe renal disease.
• Lung - No specific contraindications or precautions related to lung conditions are generally associated with letrozole.

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